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Titolo:
Promotion of collateral growth by granulocyte-macrophage colony-stimulating factor in patients with coronary artery disease - A randomized, double-blind, placebo-controlled study
Autore:
Seiler, C; Pohl, T; Wustmann, K; Hutter, D; Nicolet, PA; Windecker, S; Eberli, FR; Meier, B;
Indirizzi:
Univ Hosp Bern, Swiss Cardiovasc Ctr Bern, CH-3010 Bern, Switzerland Univ Hosp Bern Bern Switzerland CH-3010 Bern, CH-3010 Bern, Switzerland
Titolo Testata:
CIRCULATION
fascicolo: 17, volume: 104, anno: 2001,
pagine: 2012 - 2017
SICI:
0009-7322(20011023)104:17<2012:POCGBG>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-DISEASE; GENE-THERAPY; ANGIOGENESIS; ARTERIOGENESIS; MECHANISMS;
Keywords:
coronary disease; collateral circulation; growth substances; granulocyte-macrophage colony-stimulating factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Seiler, C Univ Hosp Bern, Swiss Cardiovasc Ctr Bern, CH-3010 Bern, Switzerland Univ Hosp Bern Bern Switzerland CH-3010 3010 Bern, Switzerland
Citazione:
C. Seiler et al., "Promotion of collateral growth by granulocyte-macrophage colony-stimulating factor in patients with coronary artery disease - A randomized, double-blind, placebo-controlled study", CIRCULATION, 104(17), 2001, pp. 2012-2017

Abstract

Background-Experimentally, activated macrophages have been documented to induce vascular proliferation. Methods and Results-In 21 patients (age 74 +/-9 years) with extensive coronary artery disease not eligible for coronary artery bypass surgery, the effect of granulocyte-macrophage colony-stimulating factor (GM-CSF, Molgramostim) on quantitatively assessed collateral flow was tested in a randomized,double-blind, placebo-controlled fashion. The study protocol consisted of an invasive collateral flow index (CFI) measurement immediately before intracoronary injection of 40 mug of GM-CSF (n=10) or placebo (n=11) and after a 2-week period with subcutaneous GM-CSF (10 mug/kg) or placebo, respectively. CFI was determined by simultaneous measurement of mean aortic pressure (Pao, min Hg), distal coronary occlusive pressure (P-occl, mm Hg; using intracoronary sensor guidewires), and central venous pressure (CVP, mm Hg): CFI=(P-occl-CVP)/(P-ao-CVP). CFI, expressing collateral flow during coronary occlusion relative to normal antegrade flow during vessel patency, changed from 0.21 +/-0.14 to 0.31 +/-0.23 in the GM-CSF group (P <0.05) and from 0.30 +/-0.16 to 0.23 +/-0.11 in the placebo group (P=NS). The treatment-induced difference in CFI was +0.11 +/-0.12 in the GM-CSF group and -0.07 +/-0.12 in the placebo group (P=0.01). ECG signs of myocardial ischemia during coronary balloon occlusion occurred in 9 of 10 patients before and 5 of 10 patients after GM-CSF treatment (P=0.04), whereas they were observed in 5 of 11 patients before and 8 of 11 patients after placebo (P=NS). Conclusions-This first clinical study investigating the potential of GM-CSF to improve collateral flow in patients with coronary artery disease documents its efficacy in a short-term administration protocol.

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Documento generato il 07/04/20 alle ore 22:13:26