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Titolo:
Metabolic alterations in the prefrontal and cingulate cortices are relatedto behavioral deficits in a rodent model of attention-deficit hyperactivity disorder
Autore:
Barbelivien, A; Ruotsalainen, S; Sirvio, J;
Indirizzi:
Univ Kuopio, AI Virtanen Inst Mol Sci, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 Mol Sci, FIN-70211 Kuopio, Finland
Titolo Testata:
CEREBRAL CORTEX
fascicolo: 11, volume: 11, anno: 2001,
pagine: 1056 - 1063
SICI:
1047-3211(200111)11:11<1056:MAITPA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTROLATERAL ORBITAL CORTEX; POSITRON EMISSION TOMOGRAPHY; CEREBRAL GLUCOSE-UTILIZATION; POSTERIOR PARIETAL CORTEX; REACTION-TIME-TASK; ANIMAL-MODEL; SUSTAINED ATTENTION; CHOLINERGIC SYSTEM; BASAL FOREBRAIN; FUNCTIONAL MRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Sirvio, J Orion Corp Farmos, OrionPharma, Tengstrominkatu 8,POB 425, FIN-20101 Turku, Finland Orion Corp Farmos Tengstrominkatu 8,POB 425 Turku Finland FIN-20101
Citazione:
A. Barbelivien et al., "Metabolic alterations in the prefrontal and cingulate cortices are relatedto behavioral deficits in a rodent model of attention-deficit hyperactivity disorder", CEREB CORT, 11(11), 2001, pp. 1056-1063

Abstract

Rats with a deficit in selective attention accompanied by impulsivity can be identified using a five-choice serial reaction time task (5-CSRT) and have been proposed to represent a rodent model of attention-deficit hyperactivity disorder (AND). The aim of the present study was to investigate which brain areas are important for visuospatial attention and to test the specific hypothesis that dysfunction of the frontal cortex is related to the behavioral deficits observed in poorly performing rats. Therefore, [C-14]deoxyglucose (DG) uptake, an index of brain metabolic activity, was measured during the performance of a 5-CSRT task in two populations of rats (poorly and well-performing rats) to study the relationships between the regional brainactivity and behavioral output. While performing a 5-CSRT task, poorly performing rats exhibited lower DG uptake in the cingulate and ventrolateral orbital cortices than did well-performing rats,. Moreover, there was a positive correlation between choice accuracy and DG uptake in several areas, especially in the frontal and parietal regions, whereas there was an inverse correlation between the percentage of premature responses and DG uptake in the ventrolateral orbital and cingulate cortices. These results, which demonstrated that the poorly performing rats exhibited metabolic dysfunction in the cingulate and prefrontal cortices, provide a basis for the face validity of the rodent model of ADHD. Moreover, they suggest that the neural network of attention in rats is remarkably analogous to that described in primates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:44:23