Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Differential effects of 6-OHDA lesions of the frontal cortex and caudate nucleus on the ability to acquire an attentional set
Autore:
Crofts, HS; Dalley, JW; Collins, P; Van Denderen, JCM; Everitt, BJ; Robbins, TW; Roberts, AC;
Indirizzi:
Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3DY, England Univ Cambridge Cambridge England CB2 3DY hol, Cambridge CB2 3DY, England Univ Cambridge, Dept Anat, Cambridge CB2 3DY, England Univ Cambridge Cambridge England CB2 3DY nat, Cambridge CB2 3DY, England
Titolo Testata:
CEREBRAL CORTEX
fascicolo: 11, volume: 11, anno: 2001,
pagine: 1015 - 1026
SICI:
1047-3211(200111)11:11<1015:DEO6LO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIT HYPERACTIVITY DISORDER; MEDIAL PREFRONTAL CORTEX; MPTP-TREATED MONKEYS; CARD SORT TEST; PARKINSONS-DISEASE; COGNITIVE DEFICITS; OBJECT RETRIEVAL; 6-HYDROXYDOPAMINE LESIONS; HUNTINGTONS-DISEASE; MOTOR DEFICITS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Crofts, HS Univ Cambridge, Dept Expt Psychol, Downing Site, Cambridge CB2 3EB, England Univ Cambridge Downing Site Cambridge England CB2 3EB England
Citazione:
H.S. Crofts et al., "Differential effects of 6-OHDA lesions of the frontal cortex and caudate nucleus on the ability to acquire an attentional set", CEREB CORT, 11(11), 2001, pp. 1015-1026

Abstract

Evidence from both human and animal studies indicates that catecholamine (dopamine and noradrenaline) imbalances in the fronto-striatal circuitry areassociated with deficits in higher-order cognitive functions. The present study examined how catecholamines within this circuitry modulate attentional function, specifically the ability to develop, maintain, and shift an attentional set. Catecholamine depletions within the frontal cortex of the common marmoset impaired the ability to acquire an attentional set, and increased susceptibility to distraction from task-irrelevant stimuli. Analysis ofset-shifting performance with stimulus dimensions of varying salience suggested that frontal catecholamine depletion selectively disrupts 'top-down',but not 'bottom-up' attentional processing. In contrast, the ability to acquire and shift an attentional set remained intact following dopaminergic depletion from the caudate nucleus. However, the reduced susceptibility to distraction from task-irrelevant stimuli displayed by monkeys with dopaminergic depletions of the caudate nucleus suggests; that responding was under more rigid control by the currently rewarded stimulus. The results demonstrate opposite behavioural effects of 6-hydroxydopamine (6-OHDA) lesions in the frontal cortex and caudate nucleus in tasks requiring selective attention. Frontal catecholamine depletion caused an increase in distractibility while caudate dopamine loss induced greater focusing of responding.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:44:02