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Titolo:
Hydration and structural alterations of A-DNA. Implications for the accuracy of dna replication
Autore:
Mayer, C; Timsit, Y;
Indirizzi:
IBPC, F-75005 Paris, France IBPC Paris France F-75005IBPC, F-75005 Paris, France Univ Paris 06, LMCP, F-75252 Paris 05, France Univ Paris 06 Paris France05 v Paris 06, LMCP, F-75252 Paris 05, France
Titolo Testata:
CELLULAR AND MOLECULAR BIOLOGY
fascicolo: 5, volume: 47, anno: 2001,
pagine: 815 - 822
SICI:
0145-5680(200107)47:5<815:HASAOA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CRYSTAL-STRUCTURES; DINUCLEOTIDE STEPS; BASE SEQUENCE; FIDELITY; POLYMERASES; RECOGNITION; COMPLEXES; PATTERNS; BINDING; WATER;
Keywords:
crystal structure; methyl cytosine; dehydration; hotspot; mutagenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Timsit, Y IBPC, 13 Rue Pierre & Marie Curie, F-75005 Paris, France IBPC 13Rue Pierre & Marie Curie Paris France F-75005 s, France
Citazione:
C. Mayer e Y. Timsit, "Hydration and structural alterations of A-DNA. Implications for the accuracy of dna replication", CELL MOL B, 47(5), 2001, pp. 815-822

Abstract

The accuracy of replication, transcription and translation depends on the correct pairing of complementary bases of nucleic acids. However, sequence dependent structural variations of double helices may interfere with the fidelity of these processes in altering base pair conformations. Irregular conformations; of the template-primer DNA duplex can induce replication errors in altering the structure of the polymerase active site. However, ir mostDNA polymerases,water exclusion induces the duplex to adopt the A-conformation. In attenuating the structural variability, the A-form enhances replication fidelity. How hydration and DNA sequence modulate the structure of A-DNA is therefore a relevant question for better understanding the mechanisms of sequence directed mutagenesis. This Study is focused on the relationships between hydration and the distortion of A-DNA double helices. The crystallographic analysis of the hydration pattern of A-DNA decamers reveals that the subtle interplay of DNA sequence and hydration helps to stabilize unusual structures. These findings are discussed in the context of the accuracy of replication.

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Documento generato il 02/04/20 alle ore 11:06:53