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Titolo:
ATM, a central controller of cellular responses to DNA damage
Autore:
Khanna, KK; Lavin, MF; Jackson, SP; Mulhern, TD;
Indirizzi:
Univ Queensland, Inst Med Res, PO Royal Brisbane Hosp, Brisbane, Qld 4029,Australia Univ Queensland Brisbane Qld Australia 4029 Brisbane, Qld 4029,Australia Univ Queensland, Dept Pathol & Surg, PO Royal Brisbane Hosp, Brisbane, Qld4029, Australia Univ Queensland Brisbane Qld Australia 4029 Brisbane, Qld4029, Australia Univ Cambridge, Wellcome Trust & Canc Res Campaign Inst Canc, Cambridge CB2 1QR, England Univ Cambridge Cambridge England CB2 1QR anc, Cambridge CB2 1QR, England Univ Cambridge, Dept Biol, Cambridge CB2 1QR, England Univ Cambridge Cambridge England CB2 1QR iol, Cambridge CB2 1QR, England Univ Cambridge, Dept Zool, Cambridge CB2 1QR, England Univ Cambridge Cambridge England CB2 1QR ool, Cambridge CB2 1QR, England Univ Melbourne, Dept Biochem & Mol Biol, Parkville, Vic 3010, Australia Univ Melbourne Parkville Vic Australia 3010 arkville, Vic 3010, Australia
Titolo Testata:
CELL DEATH AND DIFFERENTIATION
fascicolo: 11, volume: 8, anno: 2001,
pagine: 1052 - 1065
SICI:
1350-9047(200111)8:11<1052:AACCOC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-STRAND BREAKS; DEPENDENT PROTEIN-KINASE; ATAXIA-TELANGIECTASIA GENE; ABL TYROSINE KINASE; RADIATION-INDUCED APOPTOSIS; HISTONE ACETYLASE COMPLEX; EARLY EMBRYONIC LETHALITY; CENTRAL-NERVOUS-SYSTEM; LIGASE-IV DEFICIENCY; PIK-RELATED KINASES;
Keywords:
ATM; p53; BRCA1; Chk1; Chk2; cell cycle checkpoints; DNA repair; apoptosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
199
Recensione:
Indirizzi per estratti:
Indirizzo: Khanna, KK Univ Queensland, Inst Med Res, PO Royal Brisbane Hosp, Brisbane, Qld 4029,Australia Univ Queensland Brisbane Qld Australia 4029 Qld 4029,Australia
Citazione:
K.K. Khanna et al., "ATM, a central controller of cellular responses to DNA damage", CELL DEAT D, 8(11), 2001, pp. 1052-1065

Abstract

Mutations in the ATM gene lead to the genetic disorder ataxia-telangiectasia. ATM encodes a protein kinase that is mainly distributed in the nucleus of proliferating cells. Recent studies reveal that ATM regulates multiple cell cycle checkpoints by phosphorylating different targets at different stages of the cell cycle. ATM also functions in the regulation of DNA repair and apoptosis, suggesting that it is a central regulator of responses to DNAdouble-strand breaks.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 13:36:36