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Titolo:
NMR velocity imaging of the flow behaviour of hyaluronan solutions
Autore:
Harding, SG; Wik, O; Helander, A; Ahnfelt, NO; Kenne, L;
Indirizzi:
Swedish Univ Agr Sci, Dept Chem, SE-75007 Uppsala, Sweden Swedish Univ AgrSci Uppsala Sweden SE-75007 m, SE-75007 Uppsala, Sweden Pharmacia & Upjohn AB, SE-75182 Uppsala, Sweden Pharmacia & Upjohn AB Uppsala Sweden SE-75182 , SE-75182 Uppsala, Sweden Q Med, SE-75228 Uppsala, Sweden Q Med Uppsala Sweden SE-75228Q Med, SE-75228 Uppsala, Sweden
Titolo Testata:
CARBOHYDRATE POLYMERS
fascicolo: 2, volume: 47, anno: 2002,
pagine: 109 - 119
SICI:
0144-8617(20020201)47:2<109:NVIOTF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR-MAGNETIC-RESONANCE; WORMLIKE MICELLES; POLYMER-SOLUTIONS; MOLECULAR-WEIGHT; COUETTE-FLOW; MICROSCOPY; SHEAR; VELOCIMETRY; VISCOSITY; RHEOMETRY;
Keywords:
NMR imaging; rheology; pipe flow; wall slip; shear banding; hyaluronic acid; hyaluronan; entangled polymers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Harding, SG Swedish Univ Agr Sci, Dept Chem, Arrheniusplan 8,POB 7015, SE-75007 Uppsala, Sweden Swedish Univ Agr Sci Arrheniusplan 8,POB 7015 Uppsala Sweden SE-75007
Citazione:
S.G. Harding et al., "NMR velocity imaging of the flow behaviour of hyaluronan solutions", CARBOHY POL, 47(2), 2002, pp. 109-119

Abstract

Hyaluronan (hyaluronic acid) solutions are widely used in medicinal applications due to their biological compatibility and rheological properties. This work uses the technique NMR velocity imaging to study the flow behaviourof hyaluronan solutions pumped through Teflon tubing. Three commercially available hyaluronan solutions, (Healon (R), Healon (R) GV and Healon (R) 5)were investigated along with a set of samples with concentrations ranging from 1 to 23 mg ml(-1) and weight average molecular weight, (M) over bar (w), between 0.3 and 5.2 x 10(6). The shape of the velocity profiles were found to vary significantly with (M) over bar (w), concentration and apparent shear rate. Transitions were observed from near Newtonian flow to shear thinning to wall slip with increasing (M) over bar (w) and concentration. Solutions with the highest (M) over bar (w) and concentration showed possible 'shear banding' effects in addition to wall slip with a distinctive region of high shear with an annulus of around 50 mum at the edge of the tube. (C) 2002 Elsevier Science Ltd. All rights reserved.

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Documento generato il 02/04/20 alle ore 22:20:10