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Titolo:
OBESITY RESEARCH CONTINUES TO SPRING LEAKS
Autore:
HARPER ME;
Indirizzi:
UNIV OTTAWA,FAC MED,DEPT BIOCHEM,451 SMYTH RD OTTAWA ON K1H 8M5 CANADA
Titolo Testata:
Clinical and investigative medicine
fascicolo: 4, volume: 20, anno: 1997,
pagine: 239 - 244
SICI:
0147-958X(1997)20:4<239:ORCTSL>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROWN ADIPOSE-TISSUE; MITOCHONDRIAL INNER MEMBRANE; RAT-LIVER MITOCHONDRIA; COLD-ACCLIMATED RATS; PROTON LEAK; NONSHIVERING THERMOGENESIS; ATP TURNOVER; BLOOD-FLOW; HEPATOCYTES; RESPIRATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Harper, "OBESITY RESEARCH CONTINUES TO SPRING LEAKS", Clinical and investigative medicine, 20(4), 1997, pp. 239-244

Abstract

Recent discoveries about the roles of 2 uncoupling proteins are changing the way we view obesity and its treatment. The author is also a coauthor of a recent Nature report that mice deficient in uncoupling protein 1 (UCP1) did not become fat, as anticipated, but lean. She found that the other uncoupling protein (UCP2) was up-regulated in the brownadipose tissue (BAT) of these mice, compensating, at least in part, for the lack of UCP1 and preventing obesity. Researchers have known for40 years that the function of BAT is heat production. In 1978, researchers discovered UCP1, the protein responsible for this function. Subsequent investigation focused on the role of this protein in staving off obesity in animal models. In the early 1990s, surprising evidence from tissues other than BAT show that 20% to 40% of resting cellular energy expenditure is used to counter a proton leak down the electrochemical gradient across the mitochondrial inner membrane. This leak was found to be related to metabolic rate; the search for the mechanism of the leak led to the discovery of UCP2. Both uncoupling proteins have been found to act as leaks in mitochondrial inner membranes, allowing the dissipation of proton motive force. These findings could lead to newtreatments for obesity and non-insulin-dependent diabetes mellitus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 05:43:32