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Titolo:
Donor-derived small cell lung carcinoma in a kidney transplant recipient
Autore:
Bodvarsson, S; Burlingham, W; Kusaka, S; Hafez, GR; Becker, BN; Pintar, T; Sollinger, HW; Albertini, MR;
Indirizzi:
Univ Wisconsin, Ctr Clin Sci 414, Sch Med, Dept Internal Med, Madison, WI 53792 USA Univ Wisconsin Madison WI USA 53792 t Internal Med, Madison, WI 53792 USA Univ Wisconsin, Sch Med, Dept Surg, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 Med, Dept Surg, Madison, WI 53706 USA Univ Wisconsin, Sch Med, Dept Pathol, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 d, Dept Pathol, Madison, WI 53706 USA
Titolo Testata:
CANCER
fascicolo: 9, volume: 92, anno: 2001,
pagine: 2429 - 2434
SICI:
0008-543X(20011101)92:9<2429:DSCLCI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLIOBLASTOMA-MULTIFORME; RENAL-TRANSPLANTATION; ORIGIN;
Keywords:
transplantation; ectopic adrenocorticotropic hormone (ACTH) production; malignancy; chemotherapy; Cushing syndrome; immunosuppression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Albertini, MR Univ Wisconsin, Ctr Clin Sci 414, Sch Med, Dept Internal Med, 600 HighlandAve, Madison, WI 53792 USA Univ Wisconsin 600 Highland Ave Madison WI USA 53792 792 USA
Citazione:
S. Bodvarsson et al., "Donor-derived small cell lung carcinoma in a kidney transplant recipient", CANCER, 92(9), 2001, pp. 2429-2434

Abstract

BACKGROUND. Transplantation of donor- derived malignancies during organ transplantation fortunately is very rare. Discontinuation of immunosuppressive medications under these circumstances has previously resulted in completetumor rejection. Ectopic adrenocorticotropic hormone (ACTH) production mayresult in Cushing syndrome and is not an uncommon paraneoplastic feature of small cell carcinoma of the lung. Theoretically, in the organ transplantation setting, the resulting high cortisol levels could suppress a tumor-rejection immune response. However, to the authors' knowledge, no such a clinical scenario has been described in the literature published to date. METHODS. A 25-year-old living related kidney transplant recipient presented with Cushing syndrome 32 months after transplantation. The donor had beendiagnosed with small cell carcinoma of the lung 22 months earlier. On further evaluation, the kidney recipient was diagnosed with donor-derived smallcell lung 3 carcinoma of the transplanted kidney. She was found to have extensive disease involving the liver and retroperitoneum. Despite discontinuation of immunosuppressive medications, the disease progressed and cortisollevels remained elevated during 6 weeks of observation. RESULTS. The patient received six cycles of cisplatin and etoposide, whichresulted in resolution of her hypercortisolemia and a complete remission of her donor-derived small cell carcinoma. At last follow-up, she was 12 months from completing her therapy and continued in complete remission. CONCLUSIONS. Donor-derived small cell carcinoma and ectopic ACTH production can occur in a patient after kidney transplantation. (C) 2001 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 12:53:11