Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Tumor-related leukocytosis is linked with poor prognosis in patients with lung carcinoma
Autore:
Kasuga, I; Makino, S; Kiyokawa, H; Katoh, H; Ebihara, Y; Ohyashiki, K;
Indirizzi:
Tokyo Med Univ, Dept Surg 1, Tokyo 1600023, Japan Tokyo Med Univ Tokyo Japan 1600023 iv, Dept Surg 1, Tokyo 1600023, Japan Tokyo Med Univ, Dept Pathol 2, Tokyo 1600023, Japan Tokyo Med Univ TokyoJapan 1600023 , Dept Pathol 2, Tokyo 1600023, Japan
Titolo Testata:
CANCER
fascicolo: 9, volume: 92, anno: 2001,
pagine: 2399 - 2405
SICI:
0008-543X(20011101)92:9<2399:TLILWP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING-FACTOR; CANCER CELL-LINE; ENZYME-IMMUNOASSAY; CSF; INTERLEUKIN-6; ESTABLISHMENT; EOSINOPHILIA; ANTIBODIES;
Keywords:
lung carcinoma; nonsmall cell lung carcinoma; leukocytosis; granulocyte-colony stimulating factor; granulocyte-macrophage-colony-stimulating factor; interleukin-6;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Ohyashiki, K Tokyo Med Univ, Dept Internal Med 1, Shinjuku Ku, 6-7-1 NishiShinjuku, Tokyo 1600023, Japan Tokyo Med Univ 6-7-1 Nishi Shinjuku Tokyo Japan 1600023 apan
Citazione:
I. Kasuga et al., "Tumor-related leukocytosis is linked with poor prognosis in patients with lung carcinoma", CANCER, 92(9), 2001, pp. 2399-2405

Abstract

BACKGROUND. Tumor-related leukocytosis is a paraneoplastic syndrome that is encountered occasionally in the clinical course of patients with lung carcinoma. Recently, autonomous production of hematopoietic cytokines (granulocyte-colony stimulating factor [G-CSF], granulocyte-macrophage-colony stimulating factor [GM-CSF], and interleukin-6 [IL-6]) were identified in some of these patients. However, the incidence and clinical characterization of this phenomenon have not been clarified. METHODS. During a 7-year period, 227 patients with carcinoma of the lung were investigated, and 33 patients were diagnosed with tumor-related leukocytosis. Except for one patient with small cell lung carcinoma, the other 32 patients had nonsmall cell lung carcinoma, and the highest incidence is recognized in large cell carcinoma. These 33 patients were examined for serum G-CSF, GM-CSF, and IL-6 levels using enzyme immunoassays and enzyme-linked immunosorbent assays. Tumor specimens were stained for antihuman cytokine (G-CSF, GM-CSF, and IL-6) monoclonal antibodies. RESULTS. Sixteen patients showed high serum G-CSF levels, 4 patients showed high serum GM-CSF levels, and 18 patients showed high serum IL-6 levels. Twelve specimens stained positively against anti-G-CSF antibody. Two specimens stained positively against anti-GM-CSF antibody, and three specimens were stained positively against anti-IL-6 antibody, including one double positive specimen for both G-CSF and IL-6. All specimens that were positive formonoclonal antibodies were from patients with nonsmall cell lung carcinoma. These patients had a poor outcome compared with the other patients. CONCLUSIONS. Tumor-related leukocytosis and cytokine production frequentlyoccur in the clinical course of lung carcinoma, and this phenomenon is related mainly to nonsmall cell lung carcinoma. Its occurrence appears to be an ominous prognostic sign in patients with lung carcinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:55:28