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Titolo:
Antidopaminergic effects of dietary tyrosine depletion in healthy subjectsand patients with manic illness
Autore:
McTavish, SFB; McPherson, MH; Harmer, CJ; Clark, L; Sharp, T; Goodwin, GM; Cowen, PJ;
Indirizzi:
Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX3 7JX, England Univ Oxford Oxford England OX3 7JX ept Psychiat, Oxford OX3 7JX, England Dept Pharmacol, Oxford, England Dept Pharmacol Oxford EnglandDept Pharmacol, Oxford, England Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford, England Univ Oxford Oxford England rneford Hosp, Dept Psychiat, Oxford, England
Titolo Testata:
BRITISH JOURNAL OF PSYCHIATRY
, volume: 179, anno: 2001,
pagine: 356 - 360
SICI:
0007-1250(200110)179:<356:AEODTD>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE RELEASE; RAPID DEPLETION; RATING-SCALE; NOREPINEPHRINE; SCHIZOPHRENIA; RELIABILITY; TRYPTOPHAN; INHIBITION; SEROTONIN; BEHAVIOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: McTavish, SFB Univ Oxford, Warneford Hosp, Dept Psychiat, Neurosci Bldg, Oxford OX3 7JX,England Univ Oxford Neurosci Bldg Oxford England OX3 7JX JX,England
Citazione:
S.F.B. McTavish et al., "Antidopaminergic effects of dietary tyrosine depletion in healthy subjectsand patients with manic illness", BR J PSYCHI, 179, 2001, pp. 356-360

Abstract

Background In rats, amino acid mixtures lacking tyrosine and its precursorphenylalanine decrease the release of dopamine produced by the psychostimulant drug amphetamine. Amphetamine has been proposed as a model for clinical mania. Aims To assess whether dietary tyrosine depletion attenuates the psychostimulant effects of methamphetamine in healthy volunteers and diminishes the severity of mania in acutely ill patients. Method Sixteen healthy volunteers received a tyrosine-free amino acid mixture and a control mixture in a double-blind crossover design 4 h before methamphetamine (0.15 mg/kg). Twenty in-patients meeting DSM-IV criteria for mania were allocated blindly and randomly to receive either the tyrosine-free mixture or the control mixture. Results The tyrosine-free mixture lowered both subjective and objective measures of the psychostimulant effects of methamphetamine. Ratings of mania were lower in the patients who received the tyrosine-free mixture. Conclusions Decreased tyrosine availability to the brain attenuates pathological increases in dopamine neurotransmission following methamphetamine administration and putatively in mania.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 00:24:44