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Titolo:
Anxiolytic actions of the substance P (NK1) receptor antagonist L-760735 and the 5-HT1A agonist 8-OH-DPAT in the social interaction test in gerbils
Autore:
Cheeta, S; Tucci, S; Sandhu, J; Williams, AR; Rupniak, NMJ; File, SE;
Indirizzi:
Univ London Kings Coll, Ctr Neurosci, Psychopharmacol Res Unit, London SE11UL, England Univ London Kings Coll London England SE1 1UL it, London SE11UL, England Merck Sharp & Dohme Ltd, Neurosci Res Ctr, Dept Pharmacol, Harlow CM20 2QR, Essex, England Merck Sharp & Dohme Ltd Harlow Essex England CM20 2QR 2QR, Essex, England
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 915, anno: 2001,
pagine: 170 - 175
SICI:
0006-8993(20011012)915:2<170:AAOTSP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL RAPHE; HUMAN BRAIN; PLUS-MAZE; RATS; ANXIETY; HIPPOCAMPUS; MODULATION; FLUOXETINE; BEHAVIOR; NKP608;
Keywords:
anxiety; benzodiazepine; fluoxetine; (+/-)-8-OH-DPAT; social interaction test; substance P (NK1) receptor antagonist;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: File, SE Univ London Kings Coll, Ctr Neurosci, Psychopharmacol Res Unit, London SE11UL, England Univ London Kings Coll London England SE1 1UL n SE11UL, England
Citazione:
S. Cheeta et al., "Anxiolytic actions of the substance P (NK1) receptor antagonist L-760735 and the 5-HT1A agonist 8-OH-DPAT in the social interaction test in gerbils", BRAIN RES, 915(2), 2001, pp. 170-175

Abstract

The gerbil social interaction test has previously detected anxiolytic effects of nicotine and diazepam. In the present study, the high affinity substance P (NK1) receptor antagonist L-760735 (3 mg/kg) significantly increasedthe time spent in social interaction, whereas its low affinity analogue L-781773 (3 mg/kg) was without effect. Diazepam (0.1 mg/kg) and the 5-HT1A receptor agonist 8-OH-DPAT (0.003 and 0.01 mg/kg) also increased social interaction, whereas an acute dose of the selective serotonin re-uptake inhibitor fluoxetine (10 mg/kg) decreased the time spent in social interaction. Diazepam (0.1 mg/kg) significantly increased locomotor activity, but this effect was independent of the increase in social interaction. The other drugs tested were without effect on locomotor activity. The present findings suggest that the gerbil social interaction may well provide a useful assay for detecting both anxiolytic and anxiogenic compounds, and suggests that the high affinity NK1 receptor antagonist L-760735 may prove to be useful as an anxiolytic therapy. (C) 2001 Elsevier Science BY. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:07:20