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Titolo:
Receptor reserve of phosphoinositide-coupled muscarinic receptors in mousehippocampus in vivo
Autore:
Bymaster, FP; Carter, PA; DeLapp, NW; Calligaro, DO; Felder, CC;
Indirizzi:
Lilly Corp Ctr, Neurosci Res Div, Indianapolis, IN 46285 USA Lilly Corp Ctr Indianapolis IN USA 46285 Div, Indianapolis, IN 46285 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 916, anno: 2001,
pagine: 165 - 171
SICI:
0006-8993(20011019)916:1-2<165:RROPMR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN KINASE-C; ALZHEIMERS-DISEASE; IN-VIVO; DIFFERENTIAL REGULATION; PYRAMIDAL CELLS; AGONIST; HYDROLYSIS; BRAIN; BINDING; XANOMELINE;
Keywords:
muscarinic M-1 receptor; phosphoinositide hydrolysis; receptor reserve; muscarinic agonist; pilocarpine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Bymaster, FP Lilly Corp Ctr, Neurosci Res Div, Indianapolis, IN 46285 USA Lilly Corp Ctr Indianapolis IN USA 46285 polis, IN 46285 USA
Citazione:
F.P. Bymaster et al., "Receptor reserve of phosphoinositide-coupled muscarinic receptors in mousehippocampus in vivo", BRAIN RES, 916(1-2), 2001, pp. 165-171

Abstract

The ability of the partial muscarinic agonist pilocarpine to increase in vivo phosphoinositide. (PI) hydrolysis in mouse brain was compared to two full agonists. Pilocarpine increased in vivo phosphoinositide (PI) hydrolysisin cortex, striatum, and to the greatest extent in the hippocampus. Pilocarpine injected either subcutaneously or intracerebroventricularly robustly increased in vivo PI hydrolysis in hippocampus up to 500% of control levelsand the increases were blocked by the muscarinic antagonist scopolamine. The increases in vivo PI hydrolysis induced by pilocarpine, were 60-75% of the magnitude of the full muscarinic agonists oxotremorine-M and cis-dioxolane. The muscarinic. M-1 preferring antagonist pirenzepine potently blocked pilocarpine-induced increases in in vivo PI hydrolysis, consistent with theincrease being mediated by M-1 receptors. Since pilocarpine is a relatively weak partial agonist, these data suggest a substantial level of receptor reserve for the PI response in mouse hippocampus. (C) 2001 Published by Elsevier Science B.V.

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Documento generato il 05/04/20 alle ore 03:36:08