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Titolo:
Effect of hyperbaric oxygen on striatal metabolites: a microdialysis studyin awake freely moving rats after MCA occlusion
Autore:
Badr, AE; Yin, W; Mychaskiw, G; Zhang, JH;
Indirizzi:
Univ Mississippi, Med Ctr, Dept Neurosurg, Jackson, MS 39216 USA Univ Mississippi Jackson MS USA 39216 pt Neurosurg, Jackson, MS 39216 USA Univ Mississippi, Med Ctr, Dept Anesthesiol, Jackson, MS 39216 USA Univ Mississippi Jackson MS USA 39216 Anesthesiol, Jackson, MS 39216 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 916, anno: 2001,
pagine: 85 - 90
SICI:
0006-8993(20011019)916:1-2<85:EOHOOS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL-ARTERY OCCLUSION; PYRUVATE-DEHYDROGENASE ACTIVITY; ENERGY METABOLITES; INTRACEREBRAL MICRODIALYSIS; ISCHEMIC STROKE; GERBIL BRAIN; AMINO-ACIDS; LACTIC-ACID; BLOOD-FLOW; REPERFUSION;
Keywords:
cerebral ischemia; hyperbaric oxygen; glucose; lactate; pyruvate; glutamate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Zhang, JH Univ Mississippi, Med Ctr, Dept Neurosurg, 2500 N State St, Jackson, MS 39216 USA Univ Mississippi 2500 N State St Jackson MS USA 39216 39216 USA
Citazione:
A.E. Badr et al., "Effect of hyperbaric oxygen on striatal metabolites: a microdialysis studyin awake freely moving rats after MCA occlusion", BRAIN RES, 916(1-2), 2001, pp. 85-90

Abstract

We have shown that hyperbaric oxygen (HBO) reduced cerebral infarction in rat middle cerebral artery occlusion model (MCAO). The present study was undertaken to evaluate the effect of HBO on ischemic striatal metabolites at different times after MCAO and reperfusion. A rat MCAO model was produced via the intraluminal filament method. After 2 h of occlusion the suture was removed and reperfusion was allowed. The rats were sacrificed at 24 h afterreperfusion. HBO treatment was administered by putting rats in the HBO chamber at 3 atmospheres absolute (ATA) HBO for I h. Glucose, lactate, pyruvate, and glutamate in striatal extracellular fluid were collected and measured by a microdialysis system at 7, 10, and 24 h after reperfusion. Glucose, pyruvate and glutamate concentrations were increased after reperfusion. HBOtreatment decreased glucose, pyruvate, and glutamate almost to the controllevel (preocclusion level). The lactate concentration remained unchanged after ischemic/reperfusion and after HBO treatment. This study suggested that altered brain energy metabolites and excitatory amino acids occurred during cerebral ischemia and and HBO regulated these striatal metabolites, which might contribute to the protective effect of HBO in cerebral ischemia. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 05/04/20 alle ore 09:27:08