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Titolo:
Cellular relations between mu-opioid receptive, GABAergic and reticulospinal neurons in the rostral ventrolateral medulla
Autore:
Milner, TA; Drake, CT; Aicher, SA;
Indirizzi:
Cornell Univ, Weill Med Coll, Div Neurobiol, Dept Neurol & Neurosci, New York, NY 10021 USA Cornell Univ New York NY USA 10021 rol & Neurosci, New York, NY 10021 USA Oregon Hlth Sci Univ, Inst Neurol Sci, Beaverton, OR 97006 USA Oregon HlthSci Univ Beaverton OR USA 97006 Sci, Beaverton, OR 97006 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 917, anno: 2001,
pagine: 1 - 14
SICI:
0006-8993(20011026)917:1<1:CRBMRG>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHENYLETHANOLAMINE N-METHYLTRANSFERASE; NUCLEUS-TRACTUS-SOLITARIUS; PRESYMPATHETIC NEURONS; TYROSINE-HYDROXYLASE; BULBOSPINAL NEURONS; ADRENERGIC-NEURONS; PRESSOR AREA; BRAIN-STEM; RAT-BRAIN; IN-VIVO;
Keywords:
ultrastructure; electron microscopy; C1 adrenergic area; enkephalin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Milner, TA Cornell Univ, Weill Med Coll, Div Neurobiol, Dept Neurol & Neurosci, 411 E69th St, New York, NY 10021 USA Cornell Univ 411 E 69th St New York NY USA 10021 , NY 10021 USA
Citazione:
T.A. Milner et al., "Cellular relations between mu-opioid receptive, GABAergic and reticulospinal neurons in the rostral ventrolateral medulla", BRAIN RES, 917(1), 2001, pp. 1-14

Abstract

Physiological studies have suggested that mu -opioid receptor (MOR) activation can both excite and inhibit reticulospinal neurons in the rostral ventrolateral medulla (RVL), possibly via influences on GABAergic neurons. Thus, to determine the cellular relationships of MORs to GABAergic neurons in the RVL, two experimental approaches were used. First, single sections through the RVL were labeled for MOR using immunoperoxidase detection and for GABA using immunogold detection and examined by electron microscopy. These studies revealed that MOR-immunoreactive (IR) terminals were smaller on average than GABA-IR terminals and formed both asymmetric and symmetric synapses, whereas GABA-IR terminals formed exclusively symmetric synapses. MOR and GABA immunoreactivities rarely co-localized. Interactions between axons andterminals containing MOR or GABA immunoreactivity were primarily: (1) direct appositions with each other; or (2) convergence onto a common dendritic target that sometimes contained either MOR or GABA immunoreactivity. Since the identity of these target dendrites mostly was unknown, a second study was designed to determine if they might be reticulospinal neurons. For this study, reticulospinal neurons were identified with a retrograde tracer and both MOR and GABA were localized in the same sections of the RVL. These studies revealed that numerous GABA-IR terminals formed symmetric synapses on the perikarya and proximal dendrites of reticulospinal neurons. In contrast, few MOR-IR terminals contacted reticulospinal perikarya and large dendrites although they were often found nearby. These results provide anatomical evidence that MOR activation by endogenous or exogenous agonists may indirectly alter GABAergic neurotransmission in the RVL either through presynaptic interactions between cells or through competing influences on postsynaptic targets. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 05/04/20 alle ore 09:37:15