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Titolo:
Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis
Autore:
Kaser, A; Brandacher, G; Steurer, W; Kaser, S; Offner, FA; Zoller, H; Theurl, I; Widder, W; Molnar, C; Ludwiczek, O; Atkins, MB; Mier, JW; Tilg, H;
Indirizzi:
Univ Innsbruck Hosp, Dept Med, Div Gastroenterol & Hepatol, A-6020 Innsbruck, Austria Univ Innsbruck Hosp Innsbruck Austria A-6020 , A-6020 Innsbruck, Austria Univ Innsbruck Hosp, Dept Med, Div Gen Internal Med, A-6020 Innsbruck, Austria Univ Innsbruck Hosp Innsbruck Austria A-6020 , A-6020 Innsbruck, Austria Univ Innsbruck Hosp, Dept Transplant Surg, A-6020 Innsbruck, Austria Univ Innsbruck Hosp Innsbruck Austria A-6020 , A-6020 Innsbruck, Austria Acad Teaching Hosp Feldkirch, Dept Pathol, Feldkirch, Austria Acad Teaching Hosp Feldkirch Feldkirch Austria thol, Feldkirch, Austria Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Hematol & Oncol,Dept Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 l & Oncol,Dept Med, Boston, MA 02115 USA
Titolo Testata:
BLOOD
fascicolo: 9, volume: 98, anno: 2001,
pagine: 2720 - 2725
SICI:
0006-4971(20011101)98:9<2720:ISTTTR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT HUMAN INTERLEUKIN-6; C-MPL LIGAND; PHASE-I TRIAL; PLATELET PRODUCTION; MEGAKARYOCYTE GROWTH; DEFICIENT MICE; BONE-MARROW; SERUM THROMBOPOIETIN; RESPONSE ELEMENT; JUNB PROMOTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Tilg, H Univ Innsbruck Hosp, Dept Med, Div Gastroenterol & Hepatol, Anichstr 35, A-6020 Innsbruck, Austria Univ Innsbruck Hosp Anichstr 35 InnsbruckAustria A-6020 Austria
Citazione:
A. Kaser et al., "Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis", BLOOD, 98(9), 2001, pp. 2720-2725

Abstract

Baseline platelet production is dependent on thrombopoietin (TPO). TPO is constitutively produced and primarily regulated by receptor-mediated uptakeby platelets. Inflammatory thrombocytosis is thought to be related to increased interleukin-6 (IL-6) levels. To address whether IL-6 might act through TPO to increase platelet counts, TPO was neutralized in vivo in C57BL/10 mice treated with IL-6, and hepatic TPO mRNA expression and TPO plasma levels were studied. Transcriptional regulation of TPO mRNA was studied in the hepatoblastoma cell line HepG2. Furthermore, TPO plasma levels were determined in IL-6-treated cancer patients. It is shown that IL-6-induced thrombocytosis in C57BL/10 mice is accompanied by enhanced hepatic TPO mRNA expression and elevated TPO plasma levels. Administration of IL-6 to cancer patients results in a corresponding increase in TPO plasma levels. IL-6 enhances TPO mRNA transcription in HepG2 cells. IL-6-induced thrombocytosis can be abrogated by neutralization of TPO, suggesting that IL-6 induces thrombocytosis through TPO. A novel pathway of TPO regulation by the Inflammatory mediator IL-6 is proposed, indicating that the number of platelets by themselves might not be the sole determinant of circulating TPO levels and thus of thrombopoiesis. This regulatory pathway might be of relevance for the understanding of reactive thrombocytosis. (C) 2001 by The American Society of Hematology.

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Documento generato il 27/11/20 alle ore 21:02:58