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Titolo:
Nicotine toxicity to the ultrastructure of the testis in rats
Autore:
Aydos, K; Guven, MC; Can, B; Ergun, A;
Indirizzi:
Ankara Univ, Sch Med, Dept Urol, TR-06100 Ankara, Turkey Ankara Univ Ankara Turkey TR-06100 d, Dept Urol, TR-06100 Ankara, Turkey Ankara Univ, Sch Med, Dept Histol & Embryol, TR-06100 Ankara, Turkey Ankara Univ Ankara Turkey TR-06100 ol & Embryol, TR-06100 Ankara, Turkey Ankara Univ, Sch Med, Dept Physiol, TR-06100 Ankara, Turkey Ankara Univ Ankara Turkey TR-06100 Dept Physiol, TR-06100 Ankara, Turkey
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 6, volume: 88, anno: 2001,
pagine: 622 - 626
SICI:
1464-4096(200110)88:6<622:NTTTUO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TESTICULAR TOXICITY; LAMINA PROPRIA; SEMINAL PLASMA; SERTOLI CELLS; MYOID CELLS; SMOKING; SPERM; ASSOCIATION; MEN; SPERMATOZOA;
Keywords:
infertility; nicotine; rat; seminiferous tubules; testis; ultrastructure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Aydos, K MESA 2, Ufuk Sitesi, Kehribar Sokak 9-47, TR-06700 Ankara, TurkeyMESA 2 Kehribar Sokak 9-47 Ankara Turkey TR-06700 Ankara, Turkey
Citazione:
K. Aydos et al., "Nicotine toxicity to the ultrastructure of the testis in rats", BJU INT, 88(6), 2001, pp. 622-626

Abstract

Objective To investigate the influence of nicotine exposure on the ultrastructure of the rat testis. Materials and methods Twenty rats were injected with nicotine at a dose of0.4 mg/100 g body weight daily for 3 months; a group of 20 control rats matched for weight and age were injected with saline only for the same duration. The testes were then harvested and examined by transmission electron microscopy. Results Rats given nicotine showed: thickening of the tunica propria, caused by an increase in the collagen fibres under the irregular basal lamina; degeneration of junctional specializations between the Sertoli cells, with malformed nuclei showing condensed chromatin; Sertoli cells with numerous polymorphic mitochondria with irregular cristae and an electron-dense matrix. The germ cells were degenerated, spermatids retained excess cytoplasm andaccumulated electron-dense lipid droplets in the cytoplasm. The acrosomes were irregular and abnormally configured. Conclusion There were ultrastructural alterations in rats exposed to nicotine that could be attributed to the detrimental effects of nicotine on germcells, peritubular structures and Sertoli cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:53:40