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Titolo:
Response to lithium maintenance treatment in bipolar disorders: comparisonof women and men
Autore:
Viguera, AC; Baldessarini, RJ; Tondo, L;
Indirizzi:
Massachusetts Gen Hosp, Psychiat Serv, Perinatal Psychopharmacol Unit, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 col Unit, Boston, MA 02114 USA Int Consortium Bipolar Disorder Res, Boston, MA USA Int Consortium BipolarDisorder Res Boston MA USA er Res, Boston, MA USA Harvard Univ, Sch Med, Consolidated Dept Psychiat, Boston, MA USA Harvard Univ Boston MA USA d, Consolidated Dept Psychiat, Boston, MA USA Massachusetts Gen Hosp, Bipolar & Psychot Disorders Program, McLean Div, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Lean Div, Boston, MA 02114 USA
Titolo Testata:
BIPOLAR DISORDERS
fascicolo: 5, volume: 3, anno: 2001,
pagine: 245 - 252
SICI:
1398-5647(200110)3:5<245:RTLMTI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANIC-DEPRESSIVE ILLNESS; GENDER; RISK;
Keywords:
bipolar I and II disorders; course of illness; depression; lithium; maintenance treatment; mania; sex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Viguera, AC Massachusetts Gen Hosp, Psychiat Serv, Perinatal Psychopharmacol Unit, Fruit St, Boston, MA 02114 USA Massachusetts Gen Hosp Fruit St Boston MA USA 02114 02114 USA
Citazione:
A.C. Viguera et al., "Response to lithium maintenance treatment in bipolar disorders: comparisonof women and men", BIPOL DIS, 3(5), 2001, pp. 245-252

Abstract

Objectives: Possible sex differences in responses to mood-stabilizing treatment remain poorly defined. Since women with bipolar disorder reportedly have more features that may predict a poor prognosis (depression and rapid cycling), we tested the hypothesis that women respond less well to lithium maintenance treatment. Methods: Clinical characteristics of 360 women and men with DSM-IV bipolarI or II disorder were compared before and during clinical lithium maintenance monotherapy in a mood disorders clinic by preliminary bivariate comparisons, multivariate analysis, and survival analysis of time stable during treatment. Results: Women (n = 229) versus men (n = 131) were: more likely to have type Il disorder (1.6 times), 3.2 years older at illness onset, more often depressed-before-manic (1.4 times), considered unipolar depressive 1.9 years longer and started maintenance treatment 5.5 years later. However, women differed little from men before treatment in overall morbidity, average episode frequency and risk of suicide attempts. Contrary to prediction, women showed non-significantly superior responses to lithium treatment, and a significant 60% longer median time before a first recurrence during treatment, despite 7% lower average serum lithium concentrations. Conclusions: Women were diagnosed as bipolar later than men with corresponding delay of lithium maintenance treatment that proved to be at least as effective as in men.

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Documento generato il 25/01/20 alle ore 19:24:23