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Titolo:
Neonatal low- and high-dose exposure to estradiol benzoate in the male rat: I. Effects on the prostate gland
Autore:
Putz, O; Schwartz, CB; Kim, S; LeBlanc, GA; Cooper, RL; Prins, GS;
Indirizzi:
Univ Illinois, Coll Med, Dept Urol, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 Med, Dept Urol, Chicago, IL 60612 USA N Carolina State Univ, Dept Environm & Mol Toxicol, Raleigh, NC 27695 USA N Carolina State Univ Raleigh NC USA 27695 Toxicol, Raleigh, NC 27695 USA US EPA, Natl Hlth & Environm Effects Res Lab MD72, Reprod Toxicol Div, Endocrinol Branch, Durham, NC 27713 USA US EPA Durham NC USA 27713 l Div, Endocrinol Branch, Durham, NC 27713 USA
Titolo Testata:
BIOLOGY OF REPRODUCTION
fascicolo: 5, volume: 65, anno: 2001,
pagine: 1496 - 1505
SICI:
0006-3363(200111)65:5<1496:NLAHET>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANDROGEN RECEPTOR EXPRESSION; REPRODUCTIVE ORGAN DEVELOPMENT; BISPHENOL-A; ESTROGEN EXPOSURE; ADULT-RAT; PRENATAL EXPOSURE; ANTERIOR PROSTATE; VENTRAL PROSTATE; SEMINAL-VESICLE; FEMALE RATS;
Keywords:
early development; environment; estradiol; prostate; puberty; steroid hormones; toxicology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Prins, GS Univ Illinois, Coll Med, Dept Urol, M-C 955,820 S Wood St, Chicago, IL 60612 USA Univ Illinois M-C 955,820 S Wood St Chicago IL USA 60612 612 USA
Citazione:
O. Putz et al., "Neonatal low- and high-dose exposure to estradiol benzoate in the male rat: I. Effects on the prostate gland", BIOL REPROD, 65(5), 2001, pp. 1496-1505

Abstract

Brief exposure of rats to high doses of natural estrogens early in life results in permanent alterations of the prostate gland, which include differentiation defects, altered gene expression, and dysplasia with aging. Whether low-dose treatments can cause similar effects in the developing prostate remains controversial. The current project was designed to determine the dose-response relationship of the prostate gland to estradiol exposure duringthe developmentally critical neonatal period in the rat. Male Sprague-Dawley (SD) rats were treated on Days 1, 3, and 5 of life by s.c. injections ofa 7-log range of doses (0.015 mug/kg to 15.0 mg/kg) of beta -estradiol-3-benzoate (EB) in 25 mul of peanut oil (Arachis) as vehicle. In a separate block, neonatal Fisher 344 (F344) rats received 0.15, 15.0, or 1500.0 mug EB/kg. Rats were killed on Postnatal Day (PND) 35 or 90, and the prostates were microdissected, weighed, and frozen for immunohistochemistry. Preputial separation and hepatic testosterone hydroxlase activities were monitored andmeasured to determine the onset of puberty. On PND 35, there was an increase in prostate weights of SD rats treated with low doses of EB and a decrease in prostate weights of SD rats treated with high doses. The low-dose effect was entirely abolished by PND 90, and only high-dose suppression of organ sizes was found. The transient nature of the effect in low-dose animals suggests an advancement of puberty as the cause for increased reproductive organ weights on PND 35. F344 rats were more sensitive than SD rats to the suppressive effects of high doses of neonatal EB on PND 90. Despite this heightened responsiveness in the F344 rats, a low-dose estrogenic effect on adult prostate weights was not observed. Thus, in the rat model a sustained effect at low doses of natural estrogens is not present in the prostate glands.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 03:51:53