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Titolo:
Histamine function in brain disorders
Autore:
Fernandez-Novoa, L; Cacabelos, R;
Indirizzi:
EuroEspes Biomed Res Ctr, Inst CNS Disorders, Dept Neurobiol, La Coruna 15166, Spain EuroEspes Biomed Res Ctr La Coruna Spain 15166 l, La Coruna 15166, Spain EuroEspes Biomed Res Ctr, Inst CNS Disorders, Dept Clin Neurosci, La Coruna 15166, Spain EuroEspes Biomed Res Ctr La Coruna Spain 15166 i, La Coruna 15166, Spain
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 2, volume: 124, anno: 2001,
pagine: 213 - 233
SICI:
0166-4328(20011015)124:2<213:HFIBD>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL ALZHEIMERS-DISEASE; CENTRAL-NERVOUS-SYSTEM; CEREBRAL ENDOTHELIAL-CELLS; MAST-CELLS; HISTIDINE-DECARBOXYLASE; RAT-BRAIN; CHRONIC-SCHIZOPHRENIA; NEURON SYSTEM; TUBEROMAMMILLARY NUCLEUS; HIPPOCAMPAL-NEURONS;
Keywords:
histamine; brain disorders; Alzheimer's disease; vascular dementia; schizophrenia; animal model; neurodegeneration; endothelial cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
137
Recensione:
Indirizzi per estratti:
Indirizzo: Cacabelos, R EuroEspes Biomed Res Ctr, Inst CNS Disorders, Dept Neurobiol,La Coruna 15166, Spain EuroEspes Biomed Res Ctr La Coruna Spain 15166 15166, Spain
Citazione:
L. Fernandez-Novoa e R. Cacabelos, "Histamine function in brain disorders", BEH BRA RES, 124(2), 2001, pp. 213-233

Abstract

The neurotransmitter histamine (HA) has been implicated in the regulation of numerous and important activities or the central nervous system as arousal, cognition, circadian rhythms and neuroendocrine regulation. The data presented here indicate the participation of the histaminergic system in central nervous system disorders, such as Alzheimer's disease and schizophrenia. We also present experimental data on histamine in an animal model of neurodegeneration and the cytotoxic effects of histamine on cultured rat endothelial cells. More studies are needed to investigate the role of the histaminergic system in central nervous system disorders. Peripheral cellular studies in health and disease, molecular studies on receptors and in vivo pharmacological studies may help us to better understand the function of the histaminergic system in health and disease. (C) 2001 Elsevier Science B.V. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 19:14:28