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Titolo:
Interactions between histaminergic and cholinergic systems in learning andmemory
Autore:
Bacciottini, L; Passani, MB; Mannaioni, PF; Blandina, P;
Indirizzi:
Univ Florence, Dipartimento Farmacol Preclin & Clin, I-50139 Florence, Italy Univ Florence Florence Italy I-50139 lin & Clin, I-50139 Florence, Italy
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 2, volume: 124, anno: 2001,
pagine: 183 - 194
SICI:
0166-4328(20011015)124:2<183:IBHACS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RATS; ACTIVE-AVOIDANCE RESPONSE; PLUS-MAZE TEST; NUCLEUS BASALIS MAGNOCELLULARIS; H-3 RECEPTOR ANTAGONIST; ACETYLCHOLINE-RELEASE; ALZHEIMERS-DISEASE; IN-VIVO; HISTIDINE-DECARBOXYLASE; ALPHA-FLUOROMETHYLHISTIDINE;
Keywords:
acetylcholine; histamine; amygdala; hippocampus; cerebral cortex; release;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
135
Recensione:
Indirizzi per estratti:
Indirizzo: Blandina, P Univ Florence, Dipartimento Farmacol Preclin & Clin, Viale G Pieraccini 6,I-50139 Florence, Italy Univ Florence Viale G Pieraccini 6 Florence Italy I-50139 aly
Citazione:
L. Bacciottini et al., "Interactions between histaminergic and cholinergic systems in learning andmemory", BEH BRA RES, 124(2), 2001, pp. 183-194

Abstract

The aim of this review is to survey biochemical, electrophysiological and behavioral evidence of the interactions between the cholinergic and histaminergic systems and evaluate their possible involvement in cognitive processes. The cholinergic system has long been implicated in cognition, and thereis a plethora of data showing that cholinergic deficits parallel cognitiveimpairments in animal models and those accompanying neurodegenerative diseases or normal aging in humans. Several other neurotransmitters, though, are clearly implicated in cognitive processes and interact with the cholinergic system. The neuromodulatory effect that histamine exerts on acetylcholine release is complex and multifarious. There is clear evidence indicating that histamine controls the release of central acetylcholine (ACh) locally in the cortex and amygdala, and activating cholinergic neurones in the nucleus basalis magnocellularis (NBM) and the medial septal area-diagonal band that project to the cortex and to the hippocampus, respectively. Extensive experimental evidence supports the involvement of histamine in learning and memory and the procognitive effects of H-3 receptor antagonists. However, any attempt to strictly correlate cholinergic/histaminergic interactions with behavioral outcomes without taking into account the contribution of otherneurotransmitter systems is illegitimate. Our understanding of the role ofhistamine in learning and memory is still at its dawn, but progresses are being made to the point of suggesting potential treatment strategies that may produce beneficial effects on neurodegenerative disorders associated with impaired cholinergic function. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:07:02