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Titolo:
Effects of histamine precursor and (R)-alpha-methylhistamine on the avoidance response in rats
Autore:
Rubio, S; Begega, A; Santin, LJ; Miranda, R; Arias, JL;
Indirizzi:
Univ Oviedo, Fac Psychol, Psychobiol Lab, Oviedo 33003, Spain Univ OviedoOviedo Spain 33003 chol, Psychobiol Lab, Oviedo 33003, Spain Fac Psychol, Area Psychobiol, Malaga, Spain Fac Psychol Malaga SpainFac Psychol, Area Psychobiol, Malaga, Spain
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 2, volume: 124, anno: 2001,
pagine: 177 - 181
SICI:
0166-4328(20011015)124:2<177:EOHPA(>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUBEROMAMMILLARY NUCLEUS REGION; AGED RATS; ALZHEIMERS-DISEASE; SELF-STIMULATION; NEURON SYSTEM; MEMORY; BRAIN; FACILITATION; LESIONS; HYPOTHALAMUS;
Keywords:
histamine; (R)-alpha-methylhistamine; L-histidine; active avoidance response; memory; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Arias, JL Univ Oviedo, Fac Psychol, Psychobiol Lab, Plaza Feijoo S-N, Oviedo 33003, Spain Univ Oviedo Plaza Feijoo S-N Oviedo Spain 33003 do 33003, Spain
Citazione:
S. Rubio et al., "Effects of histamine precursor and (R)-alpha-methylhistamine on the avoidance response in rats", BEH BRA RES, 124(2), 2001, pp. 177-181

Abstract

The aim of this work is to clarify the role of histamine in learning and memory processes. In order to do this, the effect of administration of the histamine precursor, L-histidine (HIS) and of the agonist of the H-3 receptor. (R)-alpha -methylhistamine (RAMH), on active avoidance response in rats is studied. Treatment with RAMH (10 mg/kg i.p.) increased the number of avoidance responses produced during acquisition and retention of the learning. In contrast, administration of L-his (500 mg/kg i.p.) impairs performance in the shuttle-box. These results are consistent with a role for histamine in cognitive processes and suggest that a increase in cerebral histamine levels impair the acquisition of avoidance response, whereas reduced levels facilitate this acquisition. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 02/04/20 alle ore 19:16:45