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Titolo:
Escape behavior under tonic inhibitory control of histamine H-2-receptor mediated mechanisms in the midbrain tectum
Autore:
Santos, NR; Huston, JP; Brandao, ML;
Indirizzi:
USP, FFCLRP, Dept Psicol, Lab Psicobiol, BR-14049901 Ribeirao Preto, Brazil USP Ribeirao Preto Brazil BR-14049901 BC-14049901 Ribeirao Preto, Brazil Univ Dusseldorf, Inst Physiol Psychol, D-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany Univ Dusseldorf, Ctr Biol & Med Res, D-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 2, volume: 124, anno: 2001,
pagine: 167 - 175
SICI:
0166-4328(20011015)124:2<167:EBUTIC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL PERIAQUEDUCTAL GRAY; CENTRAL NERVOUS-SYSTEM; ELEVATED PLUS-MAZE; INFERIOR COLLICULUS; ELECTRICAL-STIMULATION; TUBEROMAMMILLARY NUCLEUS; HISTIDINE-DECARBOXYLASE; SUBSTANTIA-NIGRA; 5-HT2 RECEPTORS; BRAIN;
Keywords:
histamine; defense reaction; midbrain tectum; inferior colliculus; DPAG; H-2 receptor antagonists;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Brandao, ML USP, FFCLRP, Dept Psicol, Lab Psicobiol, Campus,Av Bandeirantes 3900, BR-14049901 Ribeirao Preto, Brazil USP Campus,Av Bandeirantes 3900 Ribeirao Preto Brazil BR-14049901 BC
Citazione:
N.R. Santos et al., "Escape behavior under tonic inhibitory control of histamine H-2-receptor mediated mechanisms in the midbrain tectum", BEH BRA RES, 124(2), 2001, pp. 167-175

Abstract

The dorsal periaqueductal gray matter (DPAG). superior and inferior colliculus have been implicated in the control of defense reactions in the midbrain. Electrical and chemical stimulation of these structures induces escape behavior, usually accompanied by autonomic responses and antinociception. GABA, 5-HT, opioids, excitatory amino acids and neuropeptides have been postulated to participate in the organization of such defensive reactions in the midbrain tectum. However, little attention has been given to a possible involvement of histamine in the generation of such behavior. To examine thisissue in the present study, we assessed the effects of injections into themidbrain tectum of histamine and the H-1 and H-2 receptor antagonists, chlorpheniramine and ranitidine on the behavioral manifestations of the defense reaction. The effects of these drugs were also examined on antinociception, which has been considered to be an inherent component of the defense reaction. Thus, the animals were submitted to an open field test and after 30 min. antinociceptive behavior was measured with the aid of the tail-flick test. The results show that histamine reduced exploratory activity without causing motor deficit, as evaluated by the rotarod test. Ranitidine led to adose-dependent behavioral activation, with clear signs of fear, whereas noapparent effect was observed following injections of chlorpheniramine. Antinociception always followed the escape reaction induced by the H, receptorblocker ranitidine. The present results suggest that H, receptors may be involved in the control of escape behavior and antinociception following activation of the neural substrates of fear in the midbrain tectum. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 05/12/20 alle ore 01:29:42