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Titolo:
Importance of histamine in modulatory processes, locomotion and memory
Autore:
Philippu, A; Prast, H;
Indirizzi:
Innsbruck Univ, Dept Pharmacol & Toxicol, Inst Pharm, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 Pharm, A-6020 Innsbruck, Austria
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 2, volume: 124, anno: 2001,
pagine: 151 - 159
SICI:
0166-4328(20011015)124:2<151:IOHIMP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; NITRIC-OXIDE; VENTRAL STRIATUM; ULTRADIAN RHYTHM; POSTERIOR HYPOTHALAMUS; ACETYLCHOLINE-RELEASE; ENDOGENOUS HISTAMINE; RAT HYPOTHALAMUS; NMDA RECEPTORS; INVIVO RELEASE;
Keywords:
histamine release; H-1, H-2, H-3 receptor ligands; acetylcholine; muscarinic receptor ligands; nitric oxide (NO); EEG spectral power; memory; push-pull superfusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Prast, H Innsbruck Univ, Dept Pharmacol & Toxicol, Inst Pharm, Peter Mayr Str 1, A-6020 Innsbruck, Austria Innsbruck Univ Peter Mayr Str 1 InnsbruckAustria A-6020 Austria
Citazione:
A. Philippu e H. Prast, "Importance of histamine in modulatory processes, locomotion and memory", BEH BRA RES, 124(2), 2001, pp. 151-159

Abstract

Acetylcholine modulates histaminergic transmission via M, receptors. On the other hand, cholinergic transmission is modulated by neighbouring histaminergic neurons via H-1, H-2 and H-3 receptors. Dopaminergic and GABAergic neurons are also involved in these modulatory mechanisms. Furthermore, the release of histamine is modulated by glutamatergic neurons and nitric oxide of neuronal origin. The release of histamine in the brain oscillates according to circadian, slow ultradian and fast ultradian rhythms. Ultradian fluctuations have also been observed in the theta- and delta-frequency bands ofthe EEG spectral power. Simultaneous recordings of histamine outflow and EEG in the hypothalamus revealed that the ultradian histamine release rhythmcoincides temporally with ultradian fluctuations in the EEG spectral power. Histamine receptor ligands used in pharmaco therapy, like H, and H, antagonists, modify the frequency of the EEG fluctuations. Brain histamine seemsto be involved in memory processes, since inhibition of histamine synthesis deteriorates, while H, antagonists, histamine and histidine improve short-term memory. The latter finding may open new horizons in pharmacological treatment of memory disorders. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 21:45:43