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Titolo:
Brain histamine and feeding behavior
Autore:
Morimoto, T; Yamamoto, Y; Yamatodani, A;
Indirizzi:
Osaka Univ, Fac Med, Sch Allied Hlth Sci, Dept Med Phys, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 ed Phys, Suita, Osaka 5650871, Japan
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 2, volume: 124, anno: 2001,
pagine: 145 - 150
SICI:
0166-4328(20011015)124:2<145:BHAFB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; CENTRAL-NERVOUS-SYSTEM; FOOD-INTAKE; ALPHA-FLUOROMETHYLHISTIDINE; HISTIDINE-DECARBOXYLASE; NEURONAL HISTAMINE; RAT HYPOTHALAMUS; OBESE GENE; LOCOMOTOR-ACTIVITY; WATER-INTAKE;
Keywords:
histamine; food intake; leptin; H-1 receptor knockout mice; alpha-fluoromethylhistidine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Yamatodani, A Osaka Univ, Fac Med, Sch Allied Hlth Sci, Dept Med Phys, 1-7Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 1-7 Yamadaoka Suita Osaka Japan 5650871 71, Japan
Citazione:
T. Morimoto et al., "Brain histamine and feeding behavior", BEH BRA RES, 124(2), 2001, pp. 145-150

Abstract

Food intake is regulated by many endogenous substances, such as peptides and neurotransmitters. in the central nervous system. Based on the clinical observation that some antidepressants and antipsychotics with antihistaminic activity stimulate food intake and increase body weight, histamine has been thought to be an anorectic agent. Several lines of evidence suggest thathistamine decreases food intake via H-1-receptors (H1R) at least in the ventromedial hypothalamus or the paraventricular nucleus. Recently, mutant mice lacking H1R were generated and the interaction between the histaminergicsystem and leptin-induced suppression of food intake was evidenced by using these mice. In regulating food intake, histamine is indicated to functionally associate with neuropeptide Y, peptide YY, and bombesin. However, the question remained as to why the circadian variation in the level of histamine is inversely correlated to the pattern of feeding. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:22:59