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Titolo:
Latent inhibition and conditioning in rat strains which show differential prepulse inhibition
Autore:
Conti, LH; Palmer, AA; Vanella, JJ; Printz, MP;
Indirizzi:
Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 rmacol, La Jolla, CA 92093 USA
Titolo Testata:
BEHAVIOR GENETICS
fascicolo: 3, volume: 31, anno: 2001,
pagine: 325 - 333
SICI:
0001-8244(200105)31:3<325:LIACIR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INBRED MOUSE STRAINS; SCHIZOPHRENIC ATTENTION DISORDER; ACOUSTIC STARTLE REFLEX; D-AMPHETAMINE; MODEL; HALOPERIDOL; APOMORPHINE; SENSITIVITY; STIMULI; HABITUATION;
Keywords:
conditioning; inbred rats; latent inhibition; prepulse inhibition; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Conti, LH Univ Calif San Diego, Dept Pharmacol, 0636, La Jolla, CA 92093 USA Univ Calif San Diego 0636 La Jolla CA USA 92093 la, CA 92093 USA
Citazione:
L.H. Conti et al., "Latent inhibition and conditioning in rat strains which show differential prepulse inhibition", BEHAV GENET, 31(3), 2001, pp. 325-333

Abstract

Latent inhibition (LI) is the retardation of associative conditioning resulting from preexposure of the conditioned stimulus (CS) alone prior to conditioning. Schizophrenic patients show deficient prepulse inhibition (PPI) and, at least acutely, deficient LI as well. We recently found that Brown Norway (BN) rats show a PPI deficit compared to Wistar-Kyoto (WKY) rats. If PPI and LI depend on neural processes with common genetic substrates, then LI should be deficient in BN rats as well. Here, LI of a conditioned taste aversion was examined in BN and WKY rats. One group from each strain was preexposed to a saccharin-flavored solution (CS) the day prior to conditioning. For taste aversion conditioning, these two groups again consumed saccharin and were injected with lithium chloride (unconditioned stimulus) 10 min later. A second group from each strain was not preexposed to the CS and was treated identically during conditioning, while a third group was not conditioned (injected with sodium chloride). To test for taste aversion conditioning, saccharin was offered for 20 min/day for 3 days. Non-conditioned BN and WKY rats consumed equal amounts of saccharin on test days. In both strains, conditioned rats showed a saccharin aversion. However, conditioning was less robust in BN than in WKY rats. WKY rats showed good LI of the conditioned taste aversion in that preexposed WKY rats consumed significantly more saccharin on test days than conditioned, nonpreexposed WKY rats. PreexposedBN rats did not consume significantly more saccharin on test days than conditioned, nonpreexposed BN rats. The previously reported deficiency in PPI in the BN rats was confirmed here 1 week after the taste aversion experiment. These results suggest that BN rats show deficient LI as well as PPI and display poor associative learning, a trait also reported in schizophrenia.

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Documento generato il 27/01/20 alle ore 17:20:42