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Titolo:
Sodium-hydrogen exchange inhibition: pre-versus post-ischemic treatment
Autore:
Hurtado, C; Pierce, GN;
Indirizzi:
St Boniface Gen Hosp, Res Ctr, Div Stroke & Vasc Dis, Winnipeg, MB R2H 2A6, Canada St Boniface Gen Hosp Winnipeg MB Canada R2H 2A6 nipeg, MB R2H 2A6, Canada
Titolo Testata:
BASIC RESEARCH IN CARDIOLOGY
fascicolo: 4, volume: 96, anno: 2001,
pagine: 312 - 317
SICI:
0300-8428(200107)96:4<312:SEIPPT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NA+-H+ EXCHANGE; REDUCES INFARCT SIZE; RESIDUAL BLOOD-FLOW; ISOLATED RAT-HEART; MYOCARDIAL-ISCHEMIA; REPERFUSION INJURY; VENTRICULAR MYOCYTES; INTRACELLULAR NA+; PORCINE HEARTS; CARDIOMYOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Pierce, GN St Boniface Gen Hosp, Res Ctr, Div Stroke & Vasc Dis, 351 TacheAve, Winnipeg, MB R2H 2A6, Canada St Boniface Gen Hosp 351 Tache Ave Winnipeg MB Canada R2H 2A6 a
Citazione:
C. Hurtado e G.N. Pierce, "Sodium-hydrogen exchange inhibition: pre-versus post-ischemic treatment", BAS R CARD, 96(4), 2001, pp. 312-317

Abstract

Sodium-hydrogen exchange is involved in ischemia-reperfusion injury. Despite the strong research support for the use of sodium-hydrogen exchange blockers to protect the myocardium during ischemia-reperfusion, there is still controversy regarding the most effective time for drug delivery. Studies that initiate drug treatment immediately before or at reperfusion have given conflicting results. The conflict in results may be due to differences in the experimental design. Post-ischemic cardioprotection may be less than optimal due to the vascular permeability barrier or a limited collateral circulation. Increasing the drug dose or allowing more time for the drug to cross the vessel wall may overcome this limitation. Determining the correct dose and delivery protocol, therefore, will be critical for the generation of positive results in future clinical trials and will optimize the beneficialeffects of sodium-hydrogen exchange inhibition in the treatment of reperfusion injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:21:52