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Titolo:
Regulation of myocardial Na+/H+ exchanger activity
Autore:
Fliegel, L;
Indirizzi:
Univ Alberta, Fac Med, Dept Biochem, Edmonton, AB T6G 2H7, Canada Univ Alberta Edmonton AB Canada T6G 2H7 hem, Edmonton, AB T6G 2H7, Canada
Titolo Testata:
BASIC RESEARCH IN CARDIOLOGY
fascicolo: 4, volume: 96, anno: 2001,
pagine: 301 - 305
SICI:
0300-8428(200107)96:4<301:ROMNEA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; MESSENGER-RNA EXPRESSION; NA-H EXCHANGE; GENE-EXPRESSION; RAT MYOCARDIUM; ACTIVATION; PHOSPHORYLATION; ISOFORM-1; RABBIT; STIMULATION;
Keywords:
G proteins; hypertrophy; MAP kinase; myocardium; Na+/H+ exchanger;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Fliegel, L Univ Alberta, Fac Med, Dept Biochem, 347 Med Sci Bldg, Edmonton, AB T6G 2H7, Canada Univ Alberta 347 Med Sci Bldg Edmonton AB Canada T6G 2H7 Canada
Citazione:
L. Fliegel, "Regulation of myocardial Na+/H+ exchanger activity", BAS R CARD, 96(4), 2001, pp. 301-305

Abstract

The Na+/H+ exchanger is a plasma membrane protein, present in the myocardium, which removes intracellular protons and exchanges them with extracellular Na+. The protein comprises an N-terminal, hydrophobic, integral membranedomain that transports the ions and a C-terminal, hydrophilic region that regulates the N-terminal domain. The C-terminal domain has several sub-domains, including one region that binds calmodulin and another that is phosphorylated by protein kinases. The Na+/H+ exchanger is activated by angiotensin, endothelin and alpha (1)-adrenergic stimulation. These effectors increase phosphorylation of the C-terminal domain by protein kinases, and G proteins have been implicated in this, but their role remains to be defined. It has recently been shown that ischemia and other stimuli lead to an increasedexpression of the Na+/H+ exchanger in the myocardium. The role of this increased expression in the pathology of ischemia and reperfusion-mediated myocardial damage has yet to be determined. Recent evidence suggests that the Na+/H+ exchanger may play a key role in hypertrophy of the myocardium, and that its activation through G protein-coupled receptors may be important inmediating its effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:16:07