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Titolo:
Low-binding alleles of Fc gamma receptor types IIA and IIIA are inherited independently and are associated with systemic lupus erythematosus in Hispanic patients
Autore:
Zuniga, R; Ng, S; Peterson, MGE; Reveille, JD; Baethge, BA; Alarcon, GS; Salmon, JE;
Indirizzi:
Hosp Special Surg, New York, NY 10021 USA Hosp Special Surg New York NY USA 10021 cial Surg, New York, NY 10021 USA Cornell Univ, Weill Coll Med, New York, NY USA Cornell Univ New York NY USA nell Univ, Weill Coll Med, New York, NY USA Univ Texas, Hlth Sci Ctr, San Antonio, TX 78284 USA Univ Texas San Antonio TX USA 78284 th Sci Ctr, San Antonio, TX 78284 USA Univ Texas, Med Branch, Galveston, TX 77550 USA Univ Texas Galveston TX USA 77550 as, Med Branch, Galveston, TX 77550 USA Univ Alabama, Birmingham, AL USA Univ Alabama Birmingham AL USAUniv Alabama, Birmingham, AL USA
Titolo Testata:
ARTHRITIS AND RHEUMATISM
fascicolo: 2, volume: 44, anno: 2001,
pagine: 361 - 367
SICI:
0004-3591(200102)44:2<361:LAOFGR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
3 ETHNIC-GROUPS; IGG SUBCLASSES; FC-GAMMA-RIIIA-158F ALLELE; SOCIOECONOMIC-STATUS; KOREAN PATIENTS; RIIA ALLELES; RISK-FACTORS; POLYMORPHISM; NEPHRITIS; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Salmon, JE Hosp Special Surg, 535 E 70th St, New York, NY 10021 USA Hosp Special Surg 535 E 70th St New York NY USA 10021 10021 USA
Citazione:
R. Zuniga et al., "Low-binding alleles of Fc gamma receptor types IIA and IIIA are inherited independently and are associated with systemic lupus erythematosus in Hispanic patients", ARTH RHEUM, 44(2), 2001, pp. 361-367

Abstract

Objective. To examine the relationship between allelic polymorphisms of IgG receptors (Fc gammaR) and the development of lupus nephritis in a prospective study, and to determine the distribution of Fc gammaR haplotypes (Fc gamma RIIA and Fc gamma RIIIA genotypes) in lupus patients and disease-free control subjects. Methods. We studied 67 Hispanic systemic lupus erythematosus (SLE) patients from a prospective study of outcome and 53 disease-free control subjects. Patients were followed up longitudinally for 3 years. Fc gamma RIIA and Fcgamma RIIIA genotypes were determined using allele-specific polymerase chain reaction. Results. Nephritis was present in 28% of patients at entry into the study and in 69% at the end of 3 years. In the nephritis group (n = 46), as well as the entire SLE cohort, there was a predominance of genotypes with low-binding alleles (Fc gamma RIIa-R131 and Fc gamma RIIIa-F176) at both loci (SLE nephritis patients 89% versus controls 62%; P < 0.002; odds ratio 0.20 [95% confidence interval 0.05-0.6] for risk of nephritis in individuals homozygous for either Fc<gamma>RIIa-H131 or Fc gamma RIIIa-V176). The frequency of individuals homozygous for high-binding alleles at either locus decreased as the burden of disease increased (P < 0.002, by Mann-Whitney test). There was no linkage disequilibrium between Fc<gamma>RIIA and Fc gamma RIIIA in Hispanics, yet in the SLE patients, there was a clear overrepresentation of the Fc gamma RIIa-R131;Fc gamma RIIIa-F176 haplotype (SLE patients 48% versus controls 30%) and a decrease in the frequency of the high-binding haplotype (4% versus 23%) (P < 0.002). Conclusion. We observed an increase in the frequency of low-binding Fc<gamma>R alleles in an SLE population with a high prevalence of renal disease. The apparent selection for the Fc gamma RIIa-R131;Fc gamma RH1a-F176 haplotype in Hispanic patients suggests that low-binding alleles of both Fc gammaRIIa and Fc gamma RIIIa confer risk for SLE and may act additively in the pathogenesis of disease, whereas the high-binding haplotype Fc gamma RIIa-H131;Fc gamma RIIIa-V176 is protective, particularly in the homozygous state.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:30:37