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Titolo:
Expression of host defense scavenger receptors in spondylarthropathy
Autore:
Seta, N; Granfors, K; Sahly, H; Kuipers, JG; Song, YW; Baeten, D; Veys, EM; Maksymowych, W; Marker-Hermann, E; Gu, JR; Huang, F; Kirveskari, J; Yu, DTY;
Indirizzi:
Univ Calif Los Angeles, Rehabil Ctr 35 40, Div Rheumatol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Inst Publ Hlth, Turku, Finland Inst Publ Hlth Turku FinlandInst Publ Hlth, Turku, Finland Univ Kiel, D-24098 Kiel, Germany Univ Kiel Kiel Germany D-24098Univ Kiel, D-24098 Kiel, Germany Hannover Med Sch, D-3000 Hannover, Germany Hannover Med Sch Hannover Germany D-3000 d Sch, D-3000 Hannover, Germany Seoul Natl Univ, Seoul 151, South Korea Seoul Natl Univ Seoul South Korea 151 Natl Univ, Seoul 151, South Korea State Univ Ghent, B-9000 Ghent, Belgium State Univ Ghent Ghent Belgium B-9000 Univ Ghent, B-9000 Ghent, Belgium Univ Alberta, Edmonton, AB T6G 2M7, Canada Univ Alberta Edmonton AB Canada T6G 2M7 rta, Edmonton, AB T6G 2M7, Canada Univ Mainz, D-6500 Mainz, Germany Univ Mainz Mainz Germany D-6500Univ Mainz, D-6500 Mainz, Germany Gen Hosp, Beijing, Peoples R China Gen Hosp Beijing Peoples R ChinaGen Hosp, Beijing, Peoples R China
Titolo Testata:
ARTHRITIS AND RHEUMATISM
fascicolo: 4, volume: 44, anno: 2001,
pagine: 931 - 939
SICI:
0004-3591(200104)44:4<931:EOHDSR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE-CHAIN-REACTION; IN-VITRO; CHLAMYDIA-TRACHOMATIS; RHEUMATOID-ARTHRITIS; CELLS; HLA-B27; MARCO; VIVO; INVOLVEMENT; SYNOVIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Yu, DTY Univ Calif Los Angeles, Rehabil Ctr 35 40, Div Rheumatol, 1000 VetAve, Los Angeles, CA 90095 USA Univ Calif Los Angeles 1000 Vet Ave Los Angeles CA USA 90095 5 USA
Citazione:
N. Seta et al., "Expression of host defense scavenger receptors in spondylarthropathy", ARTH RHEUM, 44(4), 2001, pp. 931-939

Abstract

Objective. Reactive arthritis (ReA) is postulated to be caused by a defective host defense against gramnegative bacteria. HLA-B27 could play a role in this process, but does not account for the many HLA-B27 negative patients. The objective of this study was to test the expression of 3 macrophage scavenger receptors (SRs) that are responsible for innate immunity against gram-negative bacteria: SR class A type I (SR-AI), SR-AII, and the macrophagereceptor with collagenous structure (MARCO). We postulate that defects in such receptors might also contribute to the host risk factors that increasethe predisposition to ReA and perhaps other subtypes of spondylarthropathy(SpA). Methods. Peripheral blood, synovial fluid, and synovial tissue samples were obtained from patients with recent Salmonella infection, ReA, other SpA, and rheumatoid arthritis (RA). The expression of SRs receptors was assessedby semiquantitative reverse transcriptase-polymerase chain reaction. Results. Evaluation of the peripheral blood mononuclear cells (PBMC) from 4 patients who were recently infected with Salmonella, showed that PBMC from 2 patients who developed ReA expressed positive levels of MARCO, while PBMC from 2 patients who recovered from infection without sequelae did not. The synovial fluid mononuclear cells (SFMC) from some ReA patients expressedMARCO, but the levels were only moderate. The level of MARCO in the SFMC from the SpA patient group was low. In marked contrast, MARCO expression washigh in almost all samples of RA SFMC. These findings also extended to synovial tissues. Conclusion. Expression of the host defense gene MARCO was susceptible to modulation, not only during infections, but also in the inflammatory arthritis conditions RA and SpA. MARCO is a variable to be considered as a candidate factor that might contribute to ReA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:50:51