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Titolo:
Nutritionally induced changes in the peroxisome proliferator-activated receptor-alpha gene expression in liver of suckling rats are dependent on insulinaemia
Autore:
Panadero, M; Vidal, H; Herrera, E; Bocos, C;
Indirizzi:
Univ San Pablo, CEU, Fac Ciencias Expt & Tecn, Madrid, Spain Univ San Pablo Madrid Spain EU, Fac Ciencias Expt & Tecn, Madrid, Spain Fac Med R Laennec, INSERM, U449, Lyon, France Fac Med R Laennec Lyon France Med R Laennec, INSERM, U449, Lyon, France
Titolo Testata:
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
fascicolo: 2, volume: 394, anno: 2001,
pagine: 182 - 188
SICI:
0003-9861(20011015)394:2<182:NICITP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINOL-BINDING PROTEIN; ACYL-COA OXIDASE; FATTY-ACID; LIPOPROTEIN-LIPASE; PPAR-ALPHA; ADIPOSE-TISSUE; DEVELOPMENTAL-CHANGES; POTENTIAL MECHANISM; OPPOSITE REGULATION; MESSENGER-RNA;
Keywords:
PPARa; mRNA levels; suckling rats; lipids; insulin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Bocos, C Univ San Pablo, CEU, Fac Ciencias Expt & Tecn, POB 67, Madrid, Spain Univ San Pablo POB 67 Madrid Spain Tecn, POB 67, Madrid, Spain
Citazione:
M. Panadero et al., "Nutritionally induced changes in the peroxisome proliferator-activated receptor-alpha gene expression in liver of suckling rats are dependent on insulinaemia", ARCH BIOCH, 394(2), 2001, pp. 182-188

Abstract

It was previously found that the expression of peroxisome proliferator-activated receptor-alpha (PPAR alpha) was markedly augmented in the liver of suckling rats, in comparison to the fetuses and most notably to adult rats and it paralleled similar changes in hepatic lipid concentration. To determine whether these changes could be related to the high lipid content of the maternal milk and/or to hormonal status, the role of changes in nutrient availability and in plasma insulin concentration on liver expression during the perinatal stage in vivo in the rat was studied. When suckling rats were weaned on day 17, instead of on day 20, the level of hepatic PPAR alpha mRNA decreased earlier than in rats weaned later. When 10-day-old rats were force-fed with either glucose or Intralipid or a combination of both diets, it was found that, at similar low levels of plasma insulin, a high level of FFA stimulated PPAR alpha expression, whereas, at similar high plasma FFA concentrations, an elevated insulin level attenuated the increase in PPARa expression. It is proposed that both the high lipid intake and decreased plasma insulin level are responsible for the high PPAR alpha expression detected in rat neonates. (C) 2001 Academic Press.

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Documento generato il 22/10/20 alle ore 03:38:36