Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Inhibition of steroidogenesis in Leydig cells by exogenous nitric oxide occurs independently of steroidogenic acute regulatory protein (StAR) mRNA
Autore:
Dobashi, M; Fujisawa, M; Yamazaki, T; Okuda, Y; Kanzaki, M; Tatsumi, N; Tsuji, T; Okada, H; Kamidono, S;
Indirizzi:
Kobe Univ, Sch Med, Dept Urol, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 l, Chuo Ku, Kobe, Hyogo 6500017, Japan
Titolo Testata:
ARCHIVES OF ANDROLOGY
fascicolo: 3, volume: 47, anno: 2001,
pagine: 203 - 209
SICI:
0148-5016(200111/12)47:3<203:IOSILC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RIBONUCLEIC-ACID; SPERM MOTILITY;
Keywords:
Leydig cells; nitric oxide; steroidogenic acute regulatory protein; testosterone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Fujisawa, M Kobe Univ, Sch Med, Dept Urol, Chuo Ku, Kusunoki Cho, Kobe, Hyogo 6500017,Japan Kobe Univ Kusunoki Cho Kobe Hyogo Japan 6500017 6500017,Japan
Citazione:
M. Dobashi et al., "Inhibition of steroidogenesis in Leydig cells by exogenous nitric oxide occurs independently of steroidogenic acute regulatory protein (StAR) mRNA", ARCH ANDROL, 47(3), 2001, pp. 203-209

Abstract

Nitric oxide (NO) plays multiple roles in the reproductive system. The authors studied the effect of NO on LH-stimulated steroidogenesis in primary cultures of rat Leydig cells, particularly seeking a link between inhibitionof steroidogenesis and changes in expression of steroidogenic acute regulatory protein (SLAR). Sodium nitroprusside (SNP), an NO generator, did not alter basal testosterone, but dose-dependently reduced testosterone production in the Leydig cells stimulated by LH (100 ng/mL) at 3 h after addition of SNP. Induction of StAR mRNA transcripts could be detected as early as I hafter the addition of LH, but no effect was detected of SNP on LH induction of StAR mRNA. StAR, then, is not affected in the inhibition by NO of LH-stimulated steroidogenesis in Leydig cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 17:35:18