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Titolo:
Molecular aspects of parasite-vector and vector-host interactions in Leishmaniasis
Autore:
Sacks, D; Kamhawi, S;
Indirizzi:
NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA NIAID Bethesda MD USA20892 Parasit Dis Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
ANNUAL REVIEW OF MICROBIOLOGY
, volume: 55, anno: 2001,
pagine: 453 - 483
SICI:
0066-4227(2001)55:<453:MAOPAV>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLY LUTZOMYIA-LONGIPALPIS; SANDFLY PHLEBOTOMUS-PAPATASI; DIFFERENT DEVELOPMENTAL STAGES; NITRIC-OXIDE PRODUCTION; SALIVARY-GLAND LYSATE; PERITROPHIC MEMBRANE; CUTANEOUS LEISHMANIASIS; SURFACE LIPOPHOSPHOGLYCAN; MAJOR PROMASTIGOTES; BLOODMEAL DIGESTION;
Keywords:
sand flies; vector biology; lipophosphoglycan; saliva;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
133
Recensione:
Indirizzi per estratti:
Indirizzo: Sacks, D NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA NIAID Bethesda MD USA 20892 Dis Lab, NIH, Bethesda, MD 20892 USA
Citazione:
D. Sacks e S. Kamhawi, "Molecular aspects of parasite-vector and vector-host interactions in Leishmaniasis", ANN R MICRO, 55, 2001, pp. 453-483

Abstract

Leishmania-sand fly interactions are reviewed in the context of the potential barriers to the complete development of the parasite that exist within the midgut environment of phlebotomine flies and the molecular adaptations that the parasite has evolved that permit the development of transmissible infections to proceed. Cell surface and secreted phosphoglycans protect theparasite from the proteolytic activities of the blood-fed midgut, mediate attachment to the gut wall in order to maintain infection during excretion of the bloodmeal, and contribute to the formation of a biological plug in the anterior gut that may promote transmission by bite. The importance of vector saliva in modulating the host response to transmitted parasites is also reviewed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:41:39