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Titolo:
Mechanisms involved in osteoblast response to implant surface morphology
Autore:
Boyan, BD; Lohmann, CH; Dean, DD; Sylvia, VL; Cochran, DL; Schwartz, Z;
Indirizzi:
Univ Texas, Hlth Sci Ctr, San Antonio, TX 78229 USA Univ Texas San Antonio TX USA 78229 th Sci Ctr, San Antonio, TX 78229 USA Univ Gottingen, D-3400 Gottingen, Germany Univ Gottingen Gottingen Germany D-3400 ingen, D-3400 Gottingen, Germany Hebrew Univ Jerusalem, Hadassah Fac Dent Med, IL-91905 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91905 -91905 Jerusalem, Israel
Titolo Testata:
ANNUAL REVIEW OF MATERIALS RESEARCH
, volume: 31, anno: 2001,
pagine: 357 - 371
SICI:
1531-7331(2001)31:<357:MIIORT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; LATENT TGF-BETA; PROTEIN-KINASE-A; RAT TIBIAL BONE; TITANIUM IMPLANTS; STAINLESS-STEEL; CELL-LINE; ALKALINE-PHOSPHATASE; EXTRACELLULAR-MATRIX; PHOSPHOLIPASE A(2);
Keywords:
surface roughness; protein kinase C; PGE(2); titanium;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Boyan, BD Univ Texas, Hlth Sci Ctr, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA Univ Texas 7703 Floyd Curl Dr San Antonio TX USA 78229 78229 USA
Citazione:
B.D. Boyan et al., "Mechanisms involved in osteoblast response to implant surface morphology", ANN REV M R, 31, 2001, pp. 357-371

Abstract

Osteoblasts respond to surface topography with altered morphology, proliferation, and differentiation. The effects observed vary with cell culture model and the topographical features of the surface. In general, increased surface roughness is associated with decreased proliferation and increased differentiation. Cell responses to hormones, growth factors, and cytokines are altered as well, as is autocrine production of these factors. The cells interact with the surface via integrin receptors, and their expression is also surface roughness-dependent. Integrin binding to cell attachment proteins activates signal transduction cascades, including those mediated by protein kinase C and phospholipase A,. These signaling pathways are also used byregulatory factors, which results in synergistic responses. Prostaglandinsare important mediators of the surface effects, and both constitutive and inducible cyclooxygenase are involved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:53:24