Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Materials for non-viral gene delivery
Autore:
Segura, T; Shea, LD;
Indirizzi:
Northwestern Univ, Dept Chem Engn, Evanston, IL 60208 USA Northwestern Univ Evanston IL USA 60208 Chem Engn, Evanston, IL 60208 USA
Titolo Testata:
ANNUAL REVIEW OF MATERIALS RESEARCH
, volume: 31, anno: 2001,
pagine: 25 - 46
SICI:
1531-7331(2001)31:<25:MFNGD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CATIONIC LIPOSOME COMPLEXES; CENTRAL-NERVOUS-SYSTEM; POLY-L-LYSINE; PLASMID DNA; IN-VIVO; CONTROLLED-RELEASE; FOLATE RECEPTOR; MAMMALIAN-CELLS; DRUG-DELIVERY; ANTISENSE OLIGONUCLEOTIDES;
Keywords:
gene therapy; cationic lipids; cationic polymers; drug delivery; DNA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
141
Recensione:
Indirizzi per estratti:
Indirizzo: Segura, T Northwestern Univ, Dept Chem Engn, Evanston, IL 60208 USA Northwestern Univ Evanston IL USA 60208 Evanston, IL 60208 USA
Citazione:
T. Segura e L.D. Shea, "Materials for non-viral gene delivery", ANN REV M R, 31, 2001, pp. 25-46

Abstract

Novel therapeutic strategies can be envisioned based on altering the expression level of target genes involved in cellular processes and disease progression; however, our ability to efficiently manipulate gene expression is limited. Non-viral-based gene therapy provides a relatively safe approach to increase or decrease the expression of a specific gene using DNA or antisense sequences; however, synthetic systems are required to direct plasmids and oligonucleotides to a specific tissue and to enhance cellular uptake and intracellular trafficking. Numerous materials are being developed that interact with DNA to enhance its properties (e.g. stability, charge density) and thus direct its biodistribution and facilitate cellular interactions. The development of synthetic delivery systems to manipulate gene expression efficiently is a powerful tool that will ultimately lead to novel therapeutic strategies for the treatment of numerous disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:24:28