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Titolo:
HYPERINDUCIBLE EXPRESSION OF THE INTERFERON-GAMMA (IFN-GAMMA) GENE AND ITS SUPPRESSION IN SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE)
Autore:
GEREZ L; SHKOLNIK T; HIRSCHMANN O; LORBER M; ARAD G; KAEMPFER R;
Indirizzi:
HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT MOL VIROL IL-91120 JERUSALEM ISRAEL HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT MOL VIROL IL-91120 JERUSALEM ISRAEL RAMBAM MED CTR,DEPT RHEUMATOL HAIFA ISRAEL NAHARIAYA HOSP,IMMUNOL LAB NAHARIYA JAPAN
Titolo Testata:
Clinical and experimental immunology
fascicolo: 2, volume: 109, anno: 1997,
pagine: 296 - 303
SICI:
0009-9104(1997)109:2<296:HEOTI(>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-2 MESSENGER-RNA; B-LYMPHOCYTE HYPERACTIVITY; PERIPHERAL-BLOOD; RHEUMATOID-ARTHRITIS; CYTOKINE PRODUCTION; SJOGRENS-SYNDROME; DISEASE-ACTIVITY; T-CELLS; INDUCTION; MICE;
Keywords:
SYSTEMIC LUPUS ERYTHEMATOSUS; INTERFERON-GAMMA; MESSENGER-RNA; SUPPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
L. Gerez et al., "HYPERINDUCIBLE EXPRESSION OF THE INTERFERON-GAMMA (IFN-GAMMA) GENE AND ITS SUPPRESSION IN SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE)", Clinical and experimental immunology, 109(2), 1997, pp. 296-303

Abstract

Transient expression of IFN-gamma and IL-2 mRNA and its control by post-transcriptional and suppressive mechanisms were analysed in phytohaemagglutinin-induced peripheral blood mononuclear cells (PBMC) from 47patients with SLE and 31 age-matched normal donors, using quantitative hybridization with antisense RNA probes. In SLE, basal levels of gene expression did not deviate from those of normal donors, but stronglyaberrant patterns were obtained upon induction. The ratio of subjectsexhibiting highly inducible IFN-gamma gene expression in their PBMC to those showing moderate or low inducibility was increased five-fold in SLE (P = 0.003). High inducibility was observed for 43% of SLE patients and was equally pronounced in partial remission, mild or active disease. Inducibility of IL-2 mRNA, by contrast, remained similar to that for normal donors. However, regulation of IFN-gamma gene expression differed for mild SLE. Patients with mild disease showing high inducibility of IFN-gamma mRNA in their PBMC not only had the highest frequency of responders, but also the highest extent of an individual response, defined by superinduction of mRNA, to agents that relieve suppression (gamma-irradiation) or post-transcriptional down-regulation (cycloheximide). By contrast, patients with active SLE showing high IFN-gammamRNA inducibility had normal suppressive capacity as well as posttranscriptional control. Hence, both high inducibility of the IFN-gamma gene and its suppression are relevant to disease. Hyperactivation of theIFN-gamma gene may be alleviated in mild SLE by a vigorous, concomitant activation of post-transcriptional control and of cell-mediated suppression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:46:29