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Titolo:
Association of helminth infection with decreased reticulocyte counts and hemoglobin concentration in Thai falciparum malaria
Autore:
Nacher, M; Singhasivanon, P; Gay, F; Phumratanaprapin, W; Silachamroon, U; Looareesuwan, S;
Indirizzi:
Univ Paris 06, U INSERM 511, F-75634 Paris 13, France Univ Paris 06 Paris France 13 06, U INSERM 511, F-75634 Paris 13, France Mahidol Univ, Hosp Trop Dis, Fac Trop Med, Bangkok 10700, Thailand MahidolUniv Bangkok Thailand 10700 ac Trop Med, Bangkok 10700, Thailand
Titolo Testata:
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
fascicolo: 4, volume: 65, anno: 2001,
pagine: 335 - 337
SICI:
0002-9637(200110)65:4<335:AOHIWD>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-CELL DEFORMABILITY; NITRIC-OXIDE; EXPOSED CHILDREN; ANEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Nacher, M Univ Paris 06, U INSERM 511, 91 Blvd Hop, F-75634 Paris 13, France Univ Paris 06 91 Blvd Hop Paris France 13 5634 Paris 13, France
Citazione:
M. Nacher et al., "Association of helminth infection with decreased reticulocyte counts and hemoglobin concentration in Thai falciparum malaria", AM J TROP M, 65(4), 2001, pp. 335-337

Abstract

Following a study showing an association between Ascaris and protection from cerebral malaria, we conducted a cross-sectional study comparing admission hemoglobin concentrations in relation to exposure to helminth infection in 2 separate groups of patients: 111 cerebral malaria cases and 180 mild Plasmodium falciparum malaria cases. Hookworm infections were excluded. Meanhemoglobin concentrations were significantly lower in helminth-infected patients compared to those without helminths, both in the cerebral malaria group (10.1 +/- 3 [n = 47] versus 11.2 +/- 2.4 g/dl [n = 64], P = 0.04) and the mild malaria group (11 +/- 2.5 [n = 89] vs 12.2 +/- 2.7 g/dl [n = 91], P= 0.004). Median reticulocyte counts, only available in the cerebral malaria group, were lower in helminth-infected patients compared to those without helminths (15,340/23,760 per mul, P = 0.03). Adjustments for confounders such as body mass index did not alter these associations. These data are consistent with a mechanism causing anemia linked to differences in the immune response of helminth-infected patients during malaria.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:01:46