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Titolo:
Assessing coronary sinus blood flow in patients with coronary artery disease: A comparison of phase-contrast MR imaging with positron emission tomography
Autore:
Koskenvuo, JW; Hartiala, JJ; Knuuti, K; Sakuma, H; Toikka, JO; Komu, M; Saraste, M; Niemi, P;
Indirizzi:
Turku Univ Hosp, Dept Clin Physiol, FIN-20520 Turku, Finland Turku Univ Hosp Turku Finland FIN-20520 hysiol, FIN-20520 Turku, Finland Univ Turku, Turku PET Ctr, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 rku PET Ctr, FIN-20520 Turku, Finland Mie Univ Hosp, Dept Radiol, Tsu, Mie 5148507, Japan Mie Univ Hosp Tsu MieJapan 5148507 Dept Radiol, Tsu, Mie 5148507, Japan Turku Univ Hosp, Dept Radiol, FIN-20520 Turku, Finland Turku Univ Hosp Turku Finland FIN-20520 Radiol, FIN-20520 Turku, Finland
Titolo Testata:
AMERICAN JOURNAL OF ROENTGENOLOGY
fascicolo: 5, volume: 177, anno: 2001,
pagine: 1161 - 1166
SICI:
0361-803X(200111)177:5<1161:ACSBFI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR-MAGNETIC-RESONANCE; YOUNG MEN; NONINVASIVE QUANTIFICATION; N-13 AMMONIA; RESERVE; AGREEMENT; VOLUME; HUMANS; HEART; MASS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Koskenvuo, JW Turku Univ Hosp, Dept Clin Physiol, Kiinamyllynkatu 4-8, FIN-20520 Turku, Finland Turku Univ Hosp Kiinamyllynkatu 4-8 Turku Finland FIN-20520
Citazione:
J.W. Koskenvuo et al., "Assessing coronary sinus blood flow in patients with coronary artery disease: A comparison of phase-contrast MR imaging with positron emission tomography", AM J ROENTG, 177(5), 2001, pp. 1161-1166

Abstract

OBJECTIVE. This study was performed to determine whether MR imaging can beused to reliably measure global myocardial blood flow and coronary flow reserve in patients with coronary artery disease as compared with such measurements obtained by positron emission tomography (PET). SUBJECTS AND METHODS. We measured myocardial blood flow first at baseline and then after dipyridamole-induced hyperemia in 20 patients with coronary artery disease. Myocardial blood flow as revealed by MR imaging was calculated by dividing coronary sinus flow by the left ventricular mass. Coronary flow reserve was calculated by dividing the rate of hyperemic flow by the rate of baseline flow. RESULTS. Using MR imaging, myocardial blood flow at baseline was 0.73 +/- 0.23 mL.min(-1).g(-1), and at hyperemia the blood flow was 1.43 +/- 0.37 mL.min(-1). g(-1), yielding an average coronary flow reserve of 1.99 +/- 0.47. Using PET, myocardial blood flow was 0.89 +/- 0.21 mL.min(-1).g(-1) at baseline and 1.56 +/- 0.42 mL.min(-1).g(-1) at hyperemia, yielding an averagecoronary flow reserve of 1.77 +/- 0.36. The correlation of myocardial blood flow and coronary flow reserve measurements for these two methods was an r of 0.80 (p < 0.01) and an r of 0.50 (p < 0.05), respectively. CONCLUSION. This study shows that myocardial blood flow measurements obtained using MR imaging have a good correlation with corresponding PET measurements. Coronary flow reserve measurements obtained using MR imaging had only moderate correlation with PET-obtained measurements. Our results suggest that MR imaging flow quantification could potentially be used for measuringglobal myocardial blood flow in patients in whom interventional treatment for coronary artery disease is being evaluated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:32:50