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Titolo:
Cognitive and psychomotor effects of paroxetine and sertraline on healthy elderly volunteers
Autore:
Furlan, PM; Kallan, MJ; Ten Have, T; Pollock, BG; Katz, I; Lucki, I;
Indirizzi:
Univ Penn, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Psychiat, Philadelphia, PA 19104 USA
Titolo Testata:
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
fascicolo: 4, volume: 9, anno: 2001,
pagine: 429 - 438
SICI:
1064-7481(200123)9:4<429:CAPEOP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; CLINICAL IMPLICATIONS; DEPRESSED-PATIENTS; PERFORMANCE; ANTIDEPRESSANTS; PLACEBO; AGE; AMITRIPTYLINE; PHARMACOLOGY; METABOLITES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Katz, I Univ Penn, Sch Med, Dept Psychiat, 3600 Mkt St, Philadelphia, PA 19104 USA Univ Penn 3600 Mkt St Philadelphia PA USA 19104 phia, PA 19104 USA
Citazione:
P.M. Furlan et al., "Cognitive and psychomotor effects of paroxetine and sertraline on healthy elderly volunteers", AM J GER PS, 9(4), 2001, pp. 429-438

Abstract

Tbe authors evaluated the cognitive and psychomotor effects of serotonin reuptake inhibitors in health elderly volunteers. Paroxetine, sertraline, and placebo were compared for 3 weeks of testing in a double-blind study withbehavioral testing at baseline and at the end of each week. MANOVA models demonstrated no between-group differences; however, mixed-model random regression analyses revealed that Day 14 plasma paroxetine levels correlated negatively with delayed verbal recall and paired-associate learning scores. In contrast, plasma sertraline levels correlated positively with Day 7 immediate verbal recall, Day 14 tapping, and Day 21 delayed verbal recall scores, and negatively with divided-attention task scores on Day 21. Plasma paroxetine levels were associated with mild behavioral impairment at Day 14, with no other significant adverse effects. Plasma sertraline levels were associated with mild and transient behavioral changes, as well as early termination in several subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:11:29