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Titolo:
Continuation treatment of delusional depression in older adults
Autore:
Meyers, BS; Klimstra, SA; Gabriele, M; Hamilton, M; Kakuma, T; Tirumalasetti, F; Alexopoulos, GS;
Indirizzi:
Cornell Univ, New York Presbyterian Hosp, Weill Med Coll, Westchester Div,Dept Psychiat, White Plains, NY 10605 USA Cornell Univ White Plains NY USA10605 ychiat, White Plains, NY 10605 USA
Titolo Testata:
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
fascicolo: 4, volume: 9, anno: 2001,
pagine: 415 - 422
SICI:
1064-7481(200123)9:4<415:CTODDI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSYCHOTIC DEPRESSION; MAJOR DEPRESSION; ANXIOUS DEPRESSION; FOLLOW-UP; FEATURES; THERAPY; PHARMACOTHERAPY; PERPHENAZINE; FLUVOXAMINE; ANXIETY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Meyers, BS Cornell Univ, New York Presbyterian Hosp, Weill Med Coll, Westchester Div,Dept Psychiat, 21 Bloomingdale Rd, White Plains, NY 10605 USA Cornell Univ 21 Bloomingdale Rd White Plains NY USA 10605 5 USA
Citazione:
B.S. Meyers et al., "Continuation treatment of delusional depression in older adults", AM J GER PS, 9(4), 2001, pp. 415-422

Abstract

Delusional depression responds poorly to acute antidepressant monotherapy but appears to respond to intensive combination Pharmacotherapy, however, with poor short-term outcomes after initial improvement, particularly in later life, The authors compared the efficacy and safety of continuation combination therapy to monotherapy among older patients after remission from a delusional depression. Twenty-nine older adults with SCID-diagnosed major depression with delusions received continuation treatment with nortriptyline-plus-perphenazine or nortriptyline-plus-placebo under randomized double-blind conditions after achieving remission after ECT Of the 28 subjects included in efficacy analyses, 25% suffered relapses. The 'relapse frequency was nonsignificantly greater in combination therapy than in monotherapy subjects. However, combination subjects had significantly more extrapyramidal symptoms, an increased incidence of tardive dyskinesia, and a greater number offalls. Continuation treatment with a conventional antipsychotic does not decrease relapse rates but is associated with significant untoward adverse events in older persons after recovery from a delusional depression.

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Documento generato il 27/01/20 alle ore 01:26:01