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Titolo:
A twelve-week, double-blind, randomized comparison of nortriptyline and paroxetine in older depressed inpatients and outpatients
Autore:
Mulsant, BH; Pollock, BG; Nebes, R; Miller, MD; Sweet, RA; Stack, J; Houck, PR; Bensasi, S; Mazumdar, S; Reynolds, CF;
Indirizzi:
Univ Pittsburgh, Sch Med, Dept Psychiat, Intervent Res Ctr Study Latelife Mood Disorders, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA15260 sorders, Pittsburgh, PA 15260 USA VA Pittsburgh Hlth Care Syst, Educ & Clin Ctr, Pittsburgh, PA USA VA Pittsburgh Hlth Care Syst Pittsburgh PA USA n Ctr, Pittsburgh, PA USA
Titolo Testata:
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
fascicolo: 4, volume: 9, anno: 2001,
pagine: 406 - 414
SICI:
1064-7481(200123)9:4<406:ATDRCO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; ISCHEMIC-HEART-DISEASE; LATE-LIFE DEPRESSION; MAJOR DEPRESSION; ELDERLY PATIENTS; COMPARATIVE EFFICACY; CLINICAL-RESPONSE; RATING-SCALE; ANTIDEPRESSANTS; SERTRALINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Mulsant, BH Univ Pittsburgh, Western Psychiat Inst & Clin E837, 3811 OharaSt, Pittsburgh, PA 15213 USA Univ Pittsburgh 3811 Ohara St Pittsburgh PA USA 15213 5213 USA
Citazione:
B.H. Mulsant et al., "A twelve-week, double-blind, randomized comparison of nortriptyline and paroxetine in older depressed inpatients and outpatients", AM J GER PS, 9(4), 2001, pp. 406-414

Abstract

Selective serotonin reuptake inhibitors may be less efficacious than tricyclic antidepressants in the treatment of severe depression in older patients. The authors compared the 12-week clinical outcome of older depressed patients treated with nortriptyline or paroxetine in a double-blind randomizedcomparison in 116 psychiatric inpatients and outpatients (mean age: 72 +/-8 years) who presented with a major depressive episode or melancholic depression. Discontinuation and response rates were compared inpatients who began or who completed treatment. The discontinuation rate due to side effects was significantly higher with nortriptyline than with paroxetine (33% Vs. 16%). There were no significant differences between the rates of response inthe Intent-to-Treat analysis (nortriptyline: 57% vs. paroxetine: 55%), or the Completer analysis (nortriptyline: 78% vs. paroxetine: 84%). Altbough paroxetine appears to be better tolerated than nortriptyline, the efficacy of these two drugs does not appear to differ in the acute treatment of olderdepressed patients, including hospitalized patients and those with melancholic features.

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Documento generato il 20/01/20 alle ore 16:04:58