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Titolo:
Elevated blood pressure in subjects with lipodystrophy
Autore:
Sattler, FR; Qian, D; Louie, S; Johnson, D; Briggs, W; DeQuattro, V; Dube, MP;
Indirizzi:
Univ So Calif, Div Infect Dis, Dept Med, Los Angeles, CA 90089 USA Univ SoCalif Los Angeles CA USA 90089 ept Med, Los Angeles, CA 90089 USA Univ So Calif, Div Biometry, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 Sch Med, Los Angeles, CA 90089 USA Univ So Calif, Sch Pharm, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 h Pharm, Los Angeles, CA 90089 USA Univ So Calif, Dept Pharm, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 t Pharm, Los Angeles, CA 90089 USA Keck Sch Med, Dept Med, Div Cardiol, Los Angeles, CA USA Keck Sch Med LosAngeles CA USA pt Med, Div Cardiol, Los Angeles, CA USA Indiana Univ, Dept Med, Div Infect Dis, Indianapolis, IN 46204 USA IndianaUniv Indianapolis IN USA 46204 ct Dis, Indianapolis, IN 46204 USA
Titolo Testata:
AIDS
fascicolo: 15, volume: 15, anno: 2001,
pagine: 2001 - 2010
SICI:
0269-9370(20011019)15:15<2001:EBPISW>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; ADIPOSE-TISSUE DISTRIBUTION; HIV PROTEASE INHIBITORS; VIRUS-INFECTED MEN; INSULIN-RESISTANCE; FAT DISTRIBUTION; FAMILY HISTORY; ANTIRETROVIRAL THERAPY; COMPUTED-TOMOGRAPHY; BODY-COMPOSITION;
Keywords:
abdominal obesity; elevated blood pressure; fat accumulation; hypertension; lipodystrophy; metabolism; serum lipids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Sattler, FR Univ So Calif, LAC, Med Ctr, Rand Schrader Clin, Room 351,1300N Miss Rd, Los Angeles, CA 90033 USA Univ So Calif Room 351,1300 N Miss RdLos Angeles CA USA 90033
Citazione:
F.R. Sattler et al., "Elevated blood pressure in subjects with lipodystrophy", AIDS, 15(15), 2001, pp. 2001-2010

Abstract

Objectives: To assess the prevalence of elevated blood pressure in patients with lipodystrophy. Design: Case-control study. Participants: Forty-two patients with abnormal body fat (100%) and serum lipids (86%) (HIV-positive cohort) were matched by age and sex to 42 HIV-positive controls without previously diagnosed lipodystrophy and to 13 HIV-negative controls. Setting: Tertiary care, university-based, fully dedicated HIV clinic. Main outcome measures: Frequency and magnitude of elevated blood pressure during highly active antiretroviral therapy. Results: There were 23 +/- 16 and 22 +/- 12 blood pressure measurements recorded per subject over 21 +/- 11 and 22 +/- 11 months for the HIV-positivecohort and HIV-positive controls, respectively. Three or more elevated readings occurred in 74% of the cohort and in 48% of the HIV-positive controls(P = 0.01) and accounted for 38 +/- 25% versus 22 +/- 26% (P = 0.01) of the total readings, respectively. The average of the three highest systolic readings (153 +/- 17 versus 144 +/- 15 mmHg; P = 0.01) and diastolic readings (92 +/- 10 versus 87 +/- 9 mmHg; P = 0.01) was greater for the cohort than for the HIV-positive controls. Family history of hypertension was more common in the cohort than in the controls but accounted for only 13% of the log odds ratio value for elevated blood pressure in the cohort. Systolic blood pressure was correlated with waist-to-hip ratios in the cohort (r = 0.45; P = 0.003) but not in the HIV controls (r = 0.06; P = 0.68) and tended tobe related to fasting triglycerides (r = 0.34; P = 0.052) in subjects withHIV. Conclusions: Elevated blood pressure may be linked to the metabolic disorders occurring in patients with HIV, as in the dysmetabolic syndrome. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 19:34:12