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Titolo:
Contribution of Na+/Ca2+ exchanger to the regulation of myogenic tone in isolated rat small arteries
Autore:
Horiguchi, S; Watanabe, J; Kato, H; Baba, S; Shinozaki, T; Miura, M; Fukuchi, M; Kagaya, Y; Shirato, K;
Indirizzi:
Tohoku Univ, Grad Sch Med, Dept Cardiovasc Med, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan
Titolo Testata:
ACTA PHYSIOLOGICA SCANDINAVICA
fascicolo: 2, volume: 173, anno: 2001,
pagine: 167 - 173
SICI:
0001-6772(200110)173:2<167:CONETT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; PROTEIN-KINASE-C; SARCOPLASMIC-RETICULUM; NA+-CA2+ EXCHANGE;
Keywords:
Bay K 8644; extracellular Na+ concentration; membrane potential; mesenteric small arteries; myogenic tone; nifedipine; skeletal muscle small arteries; voltage dependent Ca2+ channels;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Shirato, K Tohoku Univ, Grad Sch Med, Dept Cardiovasc Med, Aoba Ku, 1-1 Seiryo Machi,Sendai, Miyagi 9808574, Japan Tohoku Univ 1-1 Seiryo Machi Sendai Miyagi Japan 9808574 Japan
Citazione:
S. Horiguchi et al., "Contribution of Na+/Ca2+ exchanger to the regulation of myogenic tone in isolated rat small arteries", ACT PHYSL S, 173(2), 2001, pp. 167-173

Abstract

The contribution of the Na+/Ca2+ exchanger to the myogenic vascular tone was examined in rat isolated skeletal muscle small arteries (A(SK)) with pronounced myogenic, tone and mesenteric small arteries (A(MS)) with little myogenic tone. Myogenic tone was assessed by the vascular inner diameter at transmural pressures of 40 and 100 mmHg. To depress the Na+/Ca2+ exchanger, the extracellular Na+ concentration ([Na+]o) was lowered from 143 to 1.2 mMby substituting choline-Cl for NaCl. The A(SK) developed significant myogenic tone and constricted further in low [Na+]o. Nifedipine (1 muM) reduced both myogenic tone and low [Na+]o-induced contraction. Because the membranepotential of A(SK) was not changed by low [Na+]o (-35 +/- 2 mV at 143 mM [Na+]o, -37 +/- 3 mV at 1.2 mM [Na+]o), depolarization-induced Ca2+ influx was not a cause of the low [Na+]o-induced contraction. The A(MS) did not develop significant myogenic tone. Although low [Na+]o also constricted Ams, the magnitude of constriction was significantly weaker than that in A(SK) (17 +/- 4 vs. 47 +/- 6%, P < 0.01, at 58 mm Na+). With Bay K 8644, A(MS) developed myogenic tone, and low [Na+]o-induced constriction was significantly increased. In conclusion, Na+/Ca2+ exchanger may play an important role in regulating myogenic tore, likely via mediating Ca2+-extrusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:06:23