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Titolo:
Brain-specific proteins in the cerebrospinal fluid of severely asphyxiatednewborn infants
Autore:
Blennow, M; Savman, K; Ilves, P; Thoresen, M; Rosengren, L;
Indirizzi:
Univ Gothenburg, Dept Cell Biol & Histol, Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden ell Biol & Histol, Gothenburg, Sweden Ulleval Univ Hosp, Oslo, Norway Ulleval Univ Hosp Oslo NorwayUlleval Univ Hosp, Oslo, Norway Univ Bristol, St Michaels Hosp, Dept Child Hlth, Bristol, Avon, England Univ Bristol Bristol Avon England ept Child Hlth, Bristol, Avon, England Tartu Univ Hosp, Dept Paediat, Tartu, Estonia Tartu Univ Hosp Tartu Estonia u Univ Hosp, Dept Paediat, Tartu, Estonia Sahlgrens Univ Hosp, Dept Paediat, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden Karolinska Inst, Astrid Lindgrens Childrens Hosp, Neonatal Programme, Stockholm, Sweden Karolinska Inst Stockholm Sweden Neonatal Programme, Stockholm, Sweden Huddinge Univ Hosp, Dept Paediat, Stockholm, Sweden Huddinge Univ Hosp Stockholm Sweden sp, Dept Paediat, Stockholm, Sweden
Titolo Testata:
ACTA PAEDIATRICA
fascicolo: 10, volume: 90, anno: 2001,
pagine: 1171 - 1175
SICI:
0803-5253(200110)90:10<1171:BPITCF>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBRILLARY ACIDIC PROTEIN; FULL-TERM INFANTS; PERINATAL ASPHYXIA; BIRTH ASPHYXIA; ENCEPHALOPATHY;
Keywords:
birth asphyxia; brain proteins; cerebrospinal fluid; glial fibrillary protein; neurofilament protein; neuron-specific enolase; protein S-100;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Blennow, M Huddinge Univ Hosp, Childrens Hosp, SE-14186 Stockholm, Sweden Huddinge Univ Hosp Stockholm Sweden SE-14186 tockholm, Sweden
Citazione:
M. Blennow et al., "Brain-specific proteins in the cerebrospinal fluid of severely asphyxiatednewborn infants", ACT PAEDIAT, 90(10), 2001, pp. 1171-1175

Abstract

Upcoming trials of neuroprotective strategies in severely asphyxiated newborn infants emphasize the need for early and objective markers of both goodand bad long-term prognosis. Traditional markers such as neurological depression and seizures are not specific. Aim: To study whether measurement in the cerebrospinal fluid of some proteins known to be specific to the central nervous system was in covariance with the clinical course and long-term prognosis. Methods: Twenty-two asphyxiated infants were included in the study and compared with a control group of 8 infants without signs of perinatalasphyxia. Cerebrospinal fluid (CSF) was collected during the first 4 d of life and analysed for neurofilament protein (NFp), glial fibrillary acidic protein (GFAp), protein S-100 and neuron-specific enolase (NSE). Results: The concentrations of all four proteins were significantly increased in the CSF of asphyxiated infants. The concentrations correlated significantly with other indicators of long-term prognosis and to neurological impairment at1 y of age, or death before that time. Specifically, concentrations were excessively high in the five infants who died. Conclusions: High concentrations of brain-specific proteins are released into the CSF of asphyxiated infants. It might therefore be useful to measurethese concentrations when excluding patients with the gravest prognosis from neuroprotective trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:50:21