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Titolo:
PANCREATIC ENDOCRINE RESPONSES TO THE PEPTIDES VIP AND PACAP IN THE CONSCIOUS CALF
Autore:
EDWARDS AV; BLOOM SR; GHATEI MA;
Indirizzi:
UNIV CAMBRIDGE,PHYSIOL LAB,DOWNING ST CAMBRIDGE CB2 3EG ENGLAND HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT MED LONDON W12 0NN ENGLAND
Titolo Testata:
Experimental physiology
fascicolo: 4, volume: 82, anno: 1997,
pagine: 717 - 727
SICI:
0958-0670(1997)82:4<717:PERTTP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLASE-ACTIVATING POLYPEPTIDE; PERFUSED RAT PANCREAS; GLUCAGON-SECRETION; INSULIN RELEASE; SPLANCHNIC NERVES; STIMULATION; CALVES; MOUSE; INNERVATION; GALANIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
A.V. Edwards et al., "PANCREATIC ENDOCRINE RESPONSES TO THE PEPTIDES VIP AND PACAP IN THE CONSCIOUS CALF", Experimental physiology, 82(4), 1997, pp. 717-727

Abstract

Pancreatic endocrine responses to vasoactive intestinal peptide (VIP), pituitary adenylate cyclase-activating peptide (PACAP) and acetylcholine have been investigated in conscious calves, while continuously monitoring aortic blood pressure and heart rate, in order to assess the effects of these neuropeptides under normal physiological conditions. VIP was found to modulate the release of pancreatic polypeptide (PP) in response to acetylcholine at a dose which had no significant effect on the release of either pancreatic glucagon or insulin. PACAP stimulated the release of insulin and the effect was potentiated during infusions of exogenous glucose. PACAP, when infused together with acetylcholine, also stimulated the release of pancreatic glucagon in the absence of exogenous glucose but not in its presence. Release of PP was stimulated during infusions of PACAP, whether or not exogenous glucose wasgiven, and this effect was found to be additive with that of acetylcholine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 13:47:04