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Titolo:
Water-miscible tocopherol is not superior to fat-soluble preparation for vitamin E absorption in cystic fibrosis
Autore:
Soltani-Frisk, S; Gronowitz, E; Andersson, H; Strandvik, B;
Indirizzi:
Univ Gothenburg, Fac Med, Dept Pediat, SE-41685 Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden SE-41685 , SE-41685 Gothenburg, Sweden Univ Gothenburg, Fac Med, Dept Clin Nutr, SE-41685 Gothenburg, Sweden UnivGothenburg Gothenburg Sweden SE-41685 , SE-41685 Gothenburg, Sweden
Titolo Testata:
ACTA PAEDIATRICA
fascicolo: 10, volume: 90, anno: 2001,
pagine: 1112 - 1115
SICI:
0803-5253(200110)90:10<1112:WTINST>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-TOCOPHEROL; E SUPPLEMENTATION; OXIDATIVE STRESS; LIVER; RRR;
Keywords:
intestinal absorption; tocopherol acetate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Strandvik, B Univ Gothenburg, Fac Med, Dept Pediat, SE-41685 Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden SE-41685 thenburg, Sweden
Citazione:
S. Soltani-Frisk et al., "Water-miscible tocopherol is not superior to fat-soluble preparation for vitamin E absorption in cystic fibrosis", ACT PAEDIAT, 90(10), 2001, pp. 1112-1115

Abstract

Vitamin E deficiency is a major problem in cystic fibrosis. Modem pancreatic enzymes may improve the absorption of fat-soluble vitamins to make waterdispersion less important. In order to compare the absorption of fat-soluble (F) and water-miscible (W) tocopheryl acetate, equivalent amounts (10 mg/kg body weight) were given to five patients with cystic fibrosis (CF) and five ageand sex-matched healthy controls. Serum was analysed for vitamin E using HPLC before and 1, 2, 3, 4, 6, 8, 10, 24 and 28 h after the oral intake. The median peak concentrations in the sera of controls were 41.9 mu mol/L after F and 39.8 mu mol/L after W preparations, corresponding values in CF patients being 21.3 and 26.8 mu mol/L, and corresponding means +/- SD were 41.6 +/- 6.7 and 38.4 +/- 3.3, and 27.1 +/- 14.5 and 28.8 +/- 8.3, respectively. Although the area under the curve was lower for W than F preparations in both CF patients and controls, these differences were not significant. Conclusion: The results in our study are consistent with those of an earlier study using the same preparation and suggest that it is not necessary touse water-miscible preparation of alpha -tocopheryl acetate in CF patientsreceiving modern pancreatic enzyme supplementation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 05:42:17