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Titolo:
SECRETORY INTERACTIONS BETWEEN THE SYMPATHETIC AND PARASYMPATHETIC INNERVATIONS OF THE SUBMANDIBULAR-GLAND IN THE ANESTHETIZED CAT
Autore:
EDWARDS AV; GARRETT JR; PROCTOR GB;
Indirizzi:
UNIV CAMBRIDGE,PHYSIOL LAB,DOWNING ST CAMBRIDGE CB2 3EG ENGLAND UNIV LONDON KINGS COLL,SCH MED & DENT,RAYNE INST,DEPT ORAL PATHOL LONDON SE5 9NU ENGLAND
Titolo Testata:
Experimental physiology
fascicolo: 4, volume: 82, anno: 1997,
pagine: 697 - 708
SICI:
0958-0670(1997)82:4<697:SIBTSA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN SECRETION; VASODILATOR RESPONSES; SALIVARY-GLANDS; PAROTID-GLAND; NITRIC-OXIDE; STIMULATION; BURSTS; RAT; KALLIKREIN; RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
A.V. Edwards et al., "SECRETORY INTERACTIONS BETWEEN THE SYMPATHETIC AND PARASYMPATHETIC INNERVATIONS OF THE SUBMANDIBULAR-GLAND IN THE ANESTHETIZED CAT", Experimental physiology, 82(4), 1997, pp. 697-708

Abstract

Interactions between the sympathetic and parasympathetic innervationsof the submandibular gland have been investigated in the anaesthetized car. At low frequencies of chorda lingual (parasympathetic) stimulation, simultaneous stimulation of the ascending cervical sympathetic nerve in bursts (20 Hz for 1 s at 10 a intervals) increased the Row Of submandibular saliva, but the effect was never more than additive. The output of protein was consistently reduced by simultaneous stimulationof both the sympathetic and parasympathetic innervations, below that evoked by stimulation of either alone. Sympathetic stimulation was more effective than parasympathetic stimulation in promoting the secretion of tissue kallikrein and peroxidase in the submandibular saliva. Theoutput of the latter enzyme, in response to sympathetic stimulation, was significantly reduced by simultaneous stimulation of the parasympathetic innervation at frequencies greater than 1 Hz, but nevertheless exceeded the amount secreted during chorda stimulation alone. Thus, this protocol provided no evidence of synergy between the two divisions of the autonomic nervous system with respect to any submandibular secretory function that was recorded. However, following the administration of a small dose of atropine (2-15 mu g kg(-1) I.V.), sufficient to block secretion during chorda stimulation alone, the flow of saliva, inresponse to sympathetic stimulation, was potentiated when superimposed on a background of parasympathetic stimulation at all frequencies that were employed. This effect was abolished by larger doses of atropine, indicating that it was dependent upon activation of muscarinic receptors, only some of which could have been blocked by the initial dose.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:42:30