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Titolo:
Distribution of basal ganglia lesions in generalized variant of Pick's disease: a clinicopathological study of four autopsy cases
Autore:
Tsuchiya, K; Ishizu, H; Nakano, I; Kita, Y; Sawabe, M; Haga, C; Kuyama, K; Nishinaka, T; Oyanagi, K; Ikeda, K; Kuroda, S;
Indirizzi:
Tokyo Metropolitan Matsuzawa Hosp, Dept Lab Med & Pathol, Setagaya Ku, Tokyo 1560057, Japan Tokyo Metropolitan Matsuzawa Hosp Tokyo Japan 1560057 kyo 1560057, Japan Tokyo Inst Psychiat, Dept Neuropathol, Tokyo, Japan Tokyo Inst Psychiat Tokyo Japan sychiat, Dept Neuropathol, Tokyo, Japan Tokyo Metropolitan Geriatr Hosp, Dept Pathol, Tokyo 173, Japan Tokyo Metropolitan Geriatr Hosp Tokyo Japan 173 Pathol, Tokyo 173, Japan Okayama Univ, Sch Med, Dept Neuropsychiat, Okayama 700, Japan Okayama Univ Okayama Japan 700 d, Dept Neuropsychiat, Okayama 700, Japan Jichi Med Sch, Dept Neurol, Minami Kawachi, Tochigi 32904, Japan Jichi MedSch Minami Kawachi Tochigi Japan 32904 hi, Tochigi 32904, Japan Tokyo Metropolitan Inst Neurosci, Dept Neuropathol, Tokyo, Japan Tokyo Metropolitan Inst Neurosci Tokyo Japan Neuropathol, Tokyo, Japan
Titolo Testata:
ACTA NEUROPATHOLOGICA
fascicolo: 5, volume: 102, anno: 2001,
pagine: 441 - 448
SICI:
0001-6322(200111)102:5<441:DOBGLI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; MOTOR-NEURON DISEASE; CYTOPLASMIC INCLUSIONS; BASOPHILIC INCLUSIONS; CORTICOBASAL DEGENERATION; DEMENTIA; BODIES;
Keywords:
amygdala; basophilic inclusion body; caudate nucleus; corticobasal degeneration; Pick's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Tsuchiya, K Tokyo Metropolitan Matsuzawa Hosp, Dept Lab Med & Pathol, Setagaya Ku, 2-1-1 Kamikitazawa, Tokyo 1560057, Japan Tokyo Metropolitan Matsuzawa Hosp 2-1-1 Kamikitazawa Tokyo Japan 1560057
Citazione:
K. Tsuchiya et al., "Distribution of basal ganglia lesions in generalized variant of Pick's disease: a clinicopathological study of four autopsy cases", ACT NEUROP, 102(5), 2001, pp. 441-448

Abstract

We investigated four Japanese autopsy cases of the generalized variant of Pick's disease (,,basophilic inclusion body disease") both clinically and pathologically, and examined the degree and distribution of the basal ganglia lesions, including the amygdala, striatum, pallidum, and substantia nigra. The lesions in the amygdala, striatum, and pallidum were classified into three categories (slight, moderate, and severe). The lesions in the substantia nigra were qualitatively judged, compared with normal controls. Extrapyramidal signs, not noticed in the generalized variant of Pick's disease, were evident in all four cases, in addition to dementia. The degree and distribution of basal ganglia lesions in all four cases were uniform: the caudate nucleus showed severe lesions, the amygdala and putamen severe to moderate lesions, and the pallidum moderate to slight lesions. The substantia nigra in all our cases showed prominent neuronal loss, probably being one of the lesions responsible for extrapyramidal signs. In the generalized variant of Pick's disease, the degree and distribution of the alterations within the basal ganglia differs from those reported in Pick's disease with Pick bodies (PDPB) and corticobasal degeneration (CBD). In PDPB, severe lesions arepresent in the amygdala with relative sparing of the substantia nigra, compatible with rare extrapyramidal signs in PDPB, while in CBD, severe lesions are found in the pallidum. and substantia nigra. These clinicopathological findings may contribute not only to the elucidation of clinicopathological hallmarks, but also to the progress of neuroimaging, in the generalized variant of Pick's disease.

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Documento generato il 29/03/20 alle ore 01:43:19