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Titolo:
Crystals of ternary protein-DNA complexes composed of DNA-binding domains of c-Myb or v-Myb, C/EBP alpha or C/EBP beta and tom-1A promoter fragment
Autore:
Tahirov, TH; Sasaki, M; Inoue-Bungo, T; Fujikawa, A; Sato, K; Kumasaka, T; Yamamoto, M; Ogata, K;
Indirizzi:
Yokohama City Univ, Sch Med, Kanagawa Acad Sci & Technol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 anagawa 2360004, Japan Yokohama City Univ, Sch Med, Dept Biol Struct, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 anagawa 2360004, Japan RIKEN, Harima Inst, Biocrystallog Technol Div, Sayo, Hyogo 6795148, Japan RIKEN Sayo Hyogo Japan 6795148 og Technol Div, Sayo, Hyogo 6795148, Japan Yokohama City Univ, Sch Med, Dept Urol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 anagawa 2360004, Japan Yokohama City Univ, Sch Med, Dept Biochem, Kanazawa Ku, Yokohama, Kanagawa2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 Kanagawa2360004, Japan RIKEN, Harima Inst, Struct Biophys Lab, Sayo, Hyogo 6795148, Japan RIKEN Sayo Hyogo Japan 6795148 ct Biophys Lab, Sayo, Hyogo 6795148, Japan
Titolo Testata:
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
, volume: 57, anno: 2001,
parte:, 11
pagine: 1655 - 1658
SICI:
0907-4449(200111)57:<1655:COTPCC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELOMONOCYTIC CELLS; ONCOGENE; GENE; DIFFERENTIATION; PROTOONCOGENE; PRODUCT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Tahirov, TH Yokohama City Univ, Sch Med, Kanagawa Acad Sci & Technol, Kanazawa Ku, 3-9Fukuura, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ 3-9 Fukuura Yokohama Kanagawa Japan 2360004
Citazione:
T.H. Tahirov et al., "Crystals of ternary protein-DNA complexes composed of DNA-binding domains of c-Myb or v-Myb, C/EBP alpha or C/EBP beta and tom-1A promoter fragment", ACT CRYST D, 57, 2001, pp. 1655-1658

Abstract

c-Myb and the C/EBP family are transcriptional regulatory factors that actin concert to regulate the expression of myeloid-specific genes. v-Myb encoded by avian myeloblastosis virus (AMV) is a mutated form of c-Myb that contains point mutations which disrupt the cooperation with C/EBPs. To understand the mechanism of the transcriptional synergy between c-Myb and C/EBPs and the effect of the v-Myb mutations on that synergy, knowledge based on their three-dimensional structures is essential. Crystals of ternary complexes, in which various combinations of the DNA-binding domains of c-Myb or v-Myb and C/EBP alpha or C/EBP beta are bound to a DNA fragment from tom-1A promoter, were obtained by the vapour-diffusion method. Complete diffractiondata sets were obtained from each native crystal and two types of iodine-derivative crystals. A three-wavelength MAD data set was also obtained from a bromine-derivative crystal.

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Documento generato il 08/04/20 alle ore 23:50:35