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Titolo:
The KICYC1 gene, a downstream region for two differentially regulated transcripts
Autore:
Freire-Picos, MA; Lombardia-Ferreira, LJ; Ramil, E; Gonzalez-Dominguez, M; Cerdan, ME;
Indirizzi:
Univ La Coruna, Dept Biol Celular & Mol, Fac Ciencias, La Coruna 15071, Spain Univ La Coruna La Coruna Spain 15071 ac Ciencias, La Coruna 15071, Spain
Titolo Testata:
YEAST
fascicolo: 14, volume: 18, anno: 2001,
pagine: 1347 - 1355
SICI:
0749-503X(200110)18:14<1347:TKGADR>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; SACCHAROMYCES-CEREVISIAE; KLUYVEROMYCES-LACTIS; 3'-END FORMATION; DNA-SEQUENCE; YEAST; SIGNALS; END; TERMINATION; EFFICIENCY;
Keywords:
cytochrome c; mRNA processing; transcriptional termination; Kluyveromyces lactis; yeast;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Freire-Picos, MA Univ La Coruna, Dept Biol Celular & Mol, Fac Ciencias, Campus La ZapateiraS-N, La Coruna 15071, Spain Univ La Coruna Campus La Zapateira S-N La Coruna Spain 15071
Citazione:
M.A. Freire-Picos et al., "The KICYC1 gene, a downstream region for two differentially regulated transcripts", YEAST, 18(14), 2001, pp. 1347-1355

Abstract

KlCYC1 encodes for cytochrome e in the yeast Kluyveromyces lactis and is transcribed in two mRNAs with different 3'-processing points. This is an uncommon transcription mechanism in yeast mRNAs. The 3' sequence encompassing the whole region that is needed to produce both mRNAs is analysed. We have determined identical processing points in K. lactis and in Saccharomyces cerevisiae cells transformed with KlCYC1; positions 698 and 1092 (with respect to the TAA) are the major polyadenylation points. This shows that the cis-elements present in the KlCYC1-untranslated region (3'-UTR) direct a processing mechanism that has been conserved in yeast. In K. lactis there is a high predominance of the shorter transcript (1.14 kb) only at the initial logarithmic growth phase. Interestingly, this growth phase-dependent regulation of 3'-UTR processing is lost when the gene is expressed in S. cerevisiae. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:51:15