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Titolo:
Foetal growth restriction in children with prothrombotic risk factors
Autore:
von Kries, R; Junker, R; Oberle, D; Kosch, A; Nowak-Gottl, U;
Indirizzi:
Univ Munster, Dept Paediat Haematol & Oncol, D-48149 Munster, Germany UnivMunster Munster Germany D-48149 l & Oncol, D-48149 Munster, Germany Univ Munich, Inst Social Paediat & Adolescent Med, Munich, Germany Univ Munich Munich Germany al Paediat & Adolescent Med, Munich, Germany Univ Munster, Dept Clin Chem & Lab Med, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 & Lab Med, D-48149 Munster, Germany Univ Munster, Dept Arteriosclerosis Res, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 rosis Res, D-48149 Munster, Germany
Titolo Testata:
THROMBOSIS AND HAEMOSTASIS
fascicolo: 4, volume: 86, anno: 2001,
pagine: 1012 - 1016
SICI:
0340-6245(200110)86:4<1012:FGRICW>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHERITED THROMBOPHILIA; VENOUS THROMBOEMBOLISM; LIPOPROTEIN(A); PLASMINOGEN; ACTIVATION; THROMBOSIS; BINDING; GENE; RETARDATION; INFARCTION;
Keywords:
foetal growth restriction; factor V G1691A; prothrombin G20210A; lipoprotein (a); protein C; protein S; antithrombin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Nowak-Gottl, U Univ Munster, Dept Paediat Haematol & Oncol, Albert Schweitzer Str 33, D-48149 Munster, Germany Univ Munster Albert Schweitzer Str 33 Munster Germany D-48149
Citazione:
R. von Kries et al., "Foetal growth restriction in children with prothrombotic risk factors", THROMB HAEM, 86(4), 2001, pp. 1012-1016

Abstract

Placental infarction is frequently observed in low birth weight children. To evaluate whether low birth weight in healthy term neonates is associatedwith foetal inherited prothrombotic risk factors this retrospective study was conducted. Outcome measures were "birth weight in the lowest quartile" and-birth weight in the lowest decile" in singletons with a gestational ageof greater than or equal to 37 weeks. The analyses were based on 375 Caucasian children screened at the Munster childhood thrombophilia centre with complete data for all prothrombotic risk factors (factor V G1691A, prothrombin G20210A, elevated lipoprotein ( a),protein C-, protein S-, antithrombin-deficiency). The proportion of children in the lowest birth weight quartile increased from 23.7% to 30.5% to 48.0% for children with no, only single heterozygous and multiple or homozygous defects respectively. The respective adjusted odds ratios (95% confidenceintervals) of thrombophilia for birth weight in the lowest quartile (lowest decile) were 1.53 (0.76-3.08) in carriers of one prothrombotic risk factor and 4.01 (1.48-10.84) in subjects carrying multiple or homozygous defects. We identified foetal thrombophilia as an additional cause of low birth weight.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:47:45